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27 Oct 2018
Consider cargo proteins that are destined for secretion to the extracellular space. For each of the following pairs of mutations or conditions, predict where the cargo will end up (ex. in the cytoplasm, a specific organelle, transport vesicles, multiple places, extracellular space) for: (i) & (ii) Each individual condition; & (iii) The combination of both.
(i) Normal Sar1 is mutated so that it hydrolyzes GTP immediately after binding GTP.
(ii) The signal recognition particle is mutated to be unable to bind to the SRP receptor.
(iii) Both
Consider cargo proteins that are destined for secretion to the extracellular space. For each of the following pairs of mutations or conditions, predict where the cargo will end up (ex. in the cytoplasm, a specific organelle, transport vesicles, multiple places, extracellular space) for: (i) & (ii) Each individual condition; & (iii) The combination of both.
(i) Normal Sar1 is mutated so that it hydrolyzes GTP immediately after binding GTP.
(ii) The signal recognition particle is mutated to be unable to bind to the SRP receptor.
(iii) Both
Reid WolffLv2
28 Oct 2018
