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29 Apr 2019
Most cell signaling pathways eventually regulate gene expression by regulating transcription factors in the nucleus. In class, we have discussed several pathways (e.g. Wnt, SMAD, NFkB, cAMP-dependent signaling, MAPK pathway, and Notch signaling) that result in transcriptional regulation by sending a protein into the nucleus. Choose 3 of these pathways and discuss: what the protein is that enters the nucleus, how it is activated by its signaling pathway, and whether the activated protein that enters the nucleus is directly responsible for binding to DNA or whether it exerts its effects by regulating transcription factors. Be specific and explain your answer.
Most cell signaling pathways eventually regulate gene expression by regulating transcription factors in the nucleus. In class, we have discussed several pathways (e.g. Wnt, SMAD, NFkB, cAMP-dependent signaling, MAPK pathway, and Notch signaling) that result in transcriptional regulation by sending a protein into the nucleus. Choose 3 of these pathways and discuss: what the protein is that enters the nucleus, how it is activated by its signaling pathway, and whether the activated protein that enters the nucleus is directly responsible for binding to DNA or whether it exerts its effects by regulating transcription factors. Be specific and explain your answer.
Bunny GreenfelderLv2
2 May 2019