BIO230H1 Lecture Notes - Lecture 8: Interactome, Cyclic Adenosine Monophosphate, Conformational Change
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BIO230H1 Full Course Notes
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Document Summary
Protein regulation: proteins undergo a number of steps in order to become fully functional. Proteins must fold properly to adopt their 3d shape. Proteins are covalently modified with chemical group. Proteins interact with other proteins and small molecules. Covalent post-translational modifications of proteins: multiple modifications can occur on the same protein. Protein p53: mutations seen in of all cancers. Sumo: kind of like ubiquitin as it is a protein that is added to other. Post-translational regulation of gene regulatory proteins proteins: protein synthesis, ligand binding, covalent modifications, addition of 2nd subunit, unmasking, stimulation of nuclear entry, release from membrane. Regulation of gene expression by pka example: protein kinase a (pka: numerous extracellular stimuli result in increased levels of the small molecule camp, activation of protein kinase a, inactive state: Two catalytic subunits: binding of camp to regulatory subunits causes a conformational change and release of catalytic subunits, pka substrates include enzymes involved in glycogen metabolism in skeletal muscle and liver.
