BIO230H1 Lecture Notes - Lecture 8: Interactome, Glycogen Synthase, Glycolysis
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BIO230H1 Full Course Notes
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Document Summary
Phosphate on ser, thr, tyr / methyl on lys: Creates histone code in chromatin: forms mono-, di-, tri-methyl lysine. Drives protein association w/ membranes (b/c fatty acid association) N-acetylglucosamine on ser, thr / ubiquitin on lys: Monoubiquitin regulates membrane protein transport in vesicles. 2 catalytic subunits (part that can do work) camp- regulatory subunits binding conformational change releases active catalytic subunits. Activated pka: promote breakdown of pka, inhibit glycogen synthesis. Adrenaline molecule binds (other processes ) release of camp binds w/ pka regulatory subunits inhibits glycogen synthase & breaks down glycogen. Glycogen breakdown pathway: glycogen glucose-1-phosphate glucose-6-phosphate glycolytic pathway. Catalytic subunits: phosphorylate specific substrates, activate target genes w/ camp. Cre: camp responsive elements (camp responsive b/c pka is camp responsive- cre = pka responsive elements) Signalling in plants: activated pka phosphorylates creb (cre binding protein, creb recruits cbp (creb binding protein) coactivator [it doesn"t directly bind to dna, activates transcription of target genes. Abscisic acid plant hormone (not a protein)
