BIO230H1 Lecture 8: L8 Regulation of the Proteome II
31 Jan 2018
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Tuesday, october 3rd, 2017 12pm-2pm (alberts et al. Regulation of genome expression: regulation of gene expression on the level of proteins (after transcription and translation, after a protein is produced, there"s still a lot of regulation to ensure that it functions when it"s supposed to. Sometimes proteins don"t fold properly, or become aberrant (not properly functional), and the cell needs to detect and remove these proteins so they don"t contribute to toxic diseases. Proteins are very crucial to the cell because they carry out most of the functions of the genome (workhorses of the cell) Proteins undergo a number of steps in order to become functional: proteins must fold properly adopt their 3d structure, proteins are covalently modified with chemical groups (e. g. , sugars, phosphate, proteins interact with other proteins and small molecules (cofactors) Sugars, -oh groups, etc. all to regulate protein function: often proteins interact with each other to carry out their appropriate functions.
