AH 3121 Chapter Notes - Chapter 4: Mhc Restriction, Exonuclease, Epitope
Document Summary
Avery welch ah 3001 immunology week 4 module 4 9/22/15 9/24/15: exquisite tcr specificity. Epitopes are the specific part of the ag molecule that binds to the receptor. Very minor differences in amino acid sequence between antigenic (microbial) epitopes will be recognized by tcr. These molecules are required for signaling to take place. Iga and igb with membrane bound ab (alpha and beta) T cell activation: requires engagement of co-receptor molecules of cd4 or cd8 which recognize portions of mhc molecules. T and b cell ag receptors: ab bind with the greatest variety of ag with the highest affinity. Affinity of tcr is low which is why the binding of t cells to apc has to be strengthened by accessory molecules. Structure of antigens bound variable heavy chain and three variable alpha chain and three. Only 1-3 amino acid residues of determinants of a peptide and polymorphic macromolecules and small residues of an mhc molecule chemicals.
