AH 3121 Chapter Notes - Chapter 4: Immunoglobulin D, Humoral Immunity, Epitope

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8 Sep 2016
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Antigen recognition in the adaptive immune system . Introduction, clones, t & b cell ag receptors, & signal transduction. Antigen receptors of lymphocytes: antibodies, t cell receptors. Development of immune repertoires: maturation and selection of b and t cells, production of diverse ag receptors. T & b cell antigen receptors: differences. B cells have membrane-bound and secreted ab (effector function) T cells only have membrane-bound receptors, no effector functions. T cells can make cytokines that have effector functions: similarities. Ag recognition is mediated by variable (v) regions of receptors (changes from cell-to-cell) Constant (c) regions are conserved (same in all the different receptors) Signaling functions are mediated by membrane associated proteins. Avery welch ah 3001 immunology week 4 module 4 9/22/15 9/24/15. Each clone has a unique specificity; potential for >109 distinct specificities. Variable (v) regions of heavy and light chains of membrane immunoglobulin. Each clone has a unique specificity; potential for >1011 distinct specificities.

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