BIOL 2060 Chapter Notes - Chapter 13.5: Carbonic Anhydrase, Reabsorption, Respiratory Acidosis
20 Apr 2018
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Su(cid:373)(cid:373)ary of kid(cid:374)ey & regulatio(cid:374) of blood pressure: direction effect of map & gfr, high map, high gfr, low water retention, sns lowers gfr through vasoconstriction. Lowers glomerular phydrostainc, decreases gfr: effects if hormones (vasopressin, ang2/aldo, anf) Loss of bicarbonate (diarrhea, urine)= gain of hydrogen. Lose h+ by vomiting, urine, hyperventilation, metabolism of organic anions. Three lines of defense: chemical buffers (immediate)- act to minimize ph by binding h+ w/anion. Less free h+ in buffered: respiratory system (fast-minutes) ph control. Hyperventilation removes h: kidney- ph control by excretion (slow- hr/days) Secretion of h+ (excretion of acid) in proximal, distal & collecting. So converted to co2 & water by carbonic anhydrase. Transported into bicarbonate & h+ again in tubular epithelium, When h+ exceeds bicarbonate, h+ must be excreted by combining with hydrogen phosphate & excreted as h2po4. Nh3 is produced from metabolism of glutamine.
