BIOL 2060 Lecture Notes - Lecture 31: Alkalosis, Vasopressin, Aldosterone

• School: York University
• Department: Biology
• Course: BIOL 2060
• Professor: Hernan Humana

Document Summary

Sympathetic nerves tell juxta cells to release renin. renin released into plasma, conversion ang2. Ang2 produced rapidly to cause vasoconstriction which decrease gfr & increase return of fluid back to vascular system: vasopressin & aldosterone get signals from hypothalamus. Once added to circulatory system they exert signals on kidney. Aldosterone acts as transcription factor to cause synthesis of na+ channels- it promotes water reabsorption indirectly & direct control of. Inhibition of atrial myocytes to produce anf: also signals in brain tell your thirsty, defe(cid:272)t i(cid:374) (cid:271)a(cid:396)o(cid:396)e(cid:272)epto(cid:396)s is that they do(cid:374)"t (cid:272)o(cid:374)ti(cid:374)ually (cid:396)espo(cid:374)se. They adapt & thei(cid:396) response decreases overtime: sig(cid:374)als & pathways do(cid:374)"t happe(cid:374) at sa(cid:373)e ti(cid:373)e. ho(cid:396)mones are slow b/c must be release, circulation to kidney & exert effect, vasopressin & aldosterone act at different speeds. Vasopressin acts faster b/c it moves premade channels to membrane. Aldosterone stimulates production of new proteins which takes longer. Vasopressin acts in minutes whereas aldosterone takes longer: aldosterone effects are longer lasting.