BIO230H1 Chapter Notes - Chapter 1: Endosome, Ldl Receptor, Cell Membrane
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BIO230H1 Full Course Notes
Verified Note
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Document Summary
Transport into the cell from the plasma membrane: endocytosis. Receptor-mediated endocytosis: macromolecules bind to complementary transmembrane receptor proteins. Ldl receptor associate with clathrin coat, endocytosis signal bind membrane- bound adaptor protein ap2 (cid:314) ap2 recruits clathrin to initiation endocytosis. Low ph (cid:314) released from receptor, delivered to lysosome (cid:314) turn into cholesterol. Low ph in endosome (cid:314) transferrin release iron (cid:314) iron-free transferrin bound to the receptor (cid:314) the complex recycles back to the plasma membrane. Escrt (endosome sorting complex required for transport) recognize and sor the ubiquitylated receptor into intraluminal vesicles. Ascular domain (cid:314) retained and transformed into late endosome. Multivesicular bodies migrate along microtubules and fuse to become endosome. Change shape and location, lose tubular domain and modify vacuolar maine. Rab protein, pip, snares and microtubules all participate. V-type atpase in the endosome membrane pump h+ from cytosolic into endosome lumen. Escrt protein complex mediate the formation of intraluminal vesicles in multivesicular bodies.
