BIO230H1 Chapter Notes - Chapter 10: Signal Recognition Particle, Transmembrane Protein, Microsome
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BIO230H1 Full Course Notes
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Lecture 10 - protein sorting synthesis of secreted. Transitional er: area of smooth er from which transport vesicles bud off. Er also sequester ca from the cytosol. Transmembrane protein: only partially translocated across er. Water soluble : fully translocated across and released into the lumen. A signal recognition particle srp direct the er final sequence to a specific receptor. Block and stop protein synthesis time for protein to be secreted into the er and not cytosol. Srp-receptor complex moves to a protein translocator insert the peptide chain into the membrane and transfer it into the lumen. Attached to the cytosolic side of er. Polypeptide chain passes through the aqueous channel in the translocator. Translocon: assembly of translocator with other accessory components. In a single- pass transmembrane protein, a single internal er signal sequence remained in the lipid bilayer as a membrane-spanning helix. By binding site in the core of translocator. Is served as a start-transfer signal and opens the pore.
