BIO 2133 Chapter Notes - Chapter Module 1: Gluten, Growth Factor, Kinesin

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9 Nov 2017
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Explain, using diagrams, how nucleotide changes result in the alteration of protein activity. Explain why some mutations do not affect protein structure and function. Describe how mutations arise and how environmental factors can increase mutation rates. Cite examples of mutations that can be bene cial to organisms. Explain why some dna damage events and dna replication errors do not result in mutations. Distinguish between loss-of-function-mutation and gain-of-function mutations and their potential consequences. Predict the most likely effects on protein structure and function of null, reduction-of-function, overexpression, dominant-negative, and gain-of-function mutations. Explain gene expression and phenotype expression in terms of dna translation and rna transcription. Gene mutations: mutations occurring primarily in the base-pair sequence of dna within individual genes. Point mutation/base substitution: a change of one base pair to another. Missense mutation: a point mutation in a triplet within a protein-coding region results in coding for a different amino acid in the protein product.

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