HTHSCI 2H03 Chapter Notes - Chapter 4: Helicobacter Pylori, Folic Acid, Lansoprazole
6 Dec 2017
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Document Summary
Peptic ulcer: a break in the gastric mucosa of 3 mm or more in size, involving the stomach or duodenum. Peptic ulcers develop when there is an imbalance between mucosal destructive and mucosal protective factors. Protective factors: mucous & bicarbonate secretions, prostaglandin e, pancreatic juices and bile, alkalization of gastric juices inhibit gastric ulcer formation. Individuals with peptic ulcer disease should avoid: smoking, alcohol, stress. Goals of pharmacotherapy for peptic ulcer disease include: relief of symptoms, ulcer healing, prevention of ulcer reoccurrence. Inspection of mucosa for signs of erosion and ulceration: mucosal biopsy- if a peptic ulcer is identified, specimens are detected to identify possible causes such as: Inflammation, nsaid injury, stress, malignancy, h. pylori infection. Serological testing: detect the presence of specific h. pylori igg antibodies in the blood. Cultures: rarely performed unless antimicrobial susceptibility testing is required (ie: if the ulcer is not responding to antimicrobial therapy).
