NURS 350 Study Guide - Uremia, Micelle, Chyme
20 Jan 2014
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May be an autoimmune disease - have antibodies against parietal cells (which are found in stomach wall) Mucosa degenerates in the body and fundus of stomach causing gastric atrophy (thinning of wall). Loss of chief (secrete pepsinogen which is converted into pepsin in the presence of gastric acid) and parietal cells (secrete hcl and if. High serum gastric levels occur due to lack of feedback inhibiting gastrin secretion - gastrin secreted by mucosa cells to stimulate hcl and pepsinogen secretion when partially digested proteins are in stomach. Pernicious anemia occurs due to loss of intrinsic factor to facilitate vitamin b12 abrosprion. Not assiciated with decrease hcl, pernicious anemia, or parietal cell antibodies. These are called erosions, they erode mucosa, but do not penetrate the muscularis mucosa. High serum levels that remain elevated longer than normal failure of feed - back mechanisms - acid in antrum inhibits gastrin release. Rapid gastric emptying alterations in protective mucosal layer due to h. pylori.
