BIOL 3051 Chapter Notes - Chapter 10.0: Peptic Ulcer, Muscularis Mucosae, Duodenum
24 Apr 2020
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Definition of pud: defect in gastric or duodenal mucosa that extends through the muscularis mucosa into the deeper layers of the wall. Pud may be present with dyspeptic or other gi symptoms, or may be initially asymptomatic and then present with complications (hemorrhage or perforation) Usually there is a balance between aggressive factors, and protective factors: puds can arise when there is an imbalance of: Nsaids (non-selective or cox 1 selective) can reduce. Prostaglandins have a protective role in the stomach, but bicarbonate secretion, prostaglandins (nsaids), mucous production, mucosal blood flow. Complications of pud: obstruction, bleeding (erosion into artery, perforation, gastric. Pud can be asymptomatic: ~70% of pu are asymptomatic, older adults and individuals on nsaids are more likely to be asymptomatic. Just because someone has dyspepsia, doesn"t mean they have an ulcer. Most people with h. pylori induced pud are asymptomatic, 10-20% result in pud. Pud can be caused by nsaids or h. pylori infections.
