Biochemistry 3381A Study Guide - Quiz Guide: Nucleoside Analogue, Intracellular Parasite, Cidofovir
20 May 2020
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Chemotherapy: specificity difficult intracellular parasites host biochemistry: less successful than bacterial counterparts: ribosome, cell wall. Ii: other chain terminators, ddc + ddi, 3tc (lamivudine, protease inhibitors: ritonavir, saquinovir, indinavir, gag and gag-pol polyprotein translation + cleavage by aspartate protease, capsid and polymerase maturation -needed for assembly, selectively inhibit hiv, not cell, proteases. Integrase inhibitors: fusion inhibitors e. g. enfuvirtide obligate intracellular parasites few processes unique to virus use host machinery. Anything w/ selective toxicity likely unique to 1 virus - hence following categorised by virus. Importance of viral infections: ebola, stds, norovirus, hpv, zika, hiv. Mainly immunomodulating or antiviral (inhibit replication i. e. not viricidal can"t inactivate whole virion) Vaccination difficult ag shift and drift 8 segments may re-assort esp upon co-infection. M2 not involved: m2: proton channel allow rna release, acidify virion core > destabilise > uncoating (rna in cytoplasm, amantadine and rimantadine (flumadine): against influenza a prevent replication, may also interfere w/ ha processing.
