PATH 3610 Study Guide - Viral Envelope, Trypsin, Chemokine
21 Feb 2014
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Enveloped with glycoprotein spikes: ha haemagglutinin, na neuraminidase, matrix. Headaches, chills, dry cough, body aches and fever. Upper respiratory symptoms; nasal congestion, stuffy nose, sore throat. Spread from person to person, coughing and sneezing. Role of na and ha proteins of influenza. Haemagglutinin (ha: binds sialic acid containing receptors, variable, role in immunity. It mediates binding of virus to host cell. Ha cleavage is essential for viral infectivity because it mediates fusion between the viral envelope and the endosome, an essential step for vrnp release to the cytoplasm. Ha cleavability is determined by cleavage site aa sequence: low pathogenic avian viruses and non-avian influenza viruses possess a single. Arg residue at the cleavage site that is cleaved by proteases in the respiratory and/or intestinal organs, and hence restricts viral replication locally: highly pathogenic h5 and h7 viruses possess several basic amino acids at the.
