MICI 2100 Lecture Notes - Lecture 15: Golgi Apparatus, Cell Membrane, Viral Evolution
Document Summary
Non-enveloped progeny escape the cell by apoptosis (programmed cell death). Enveloped progeny viruses escape the cell in the course of acquiring their lipid envelope: by budding into an internal membrane followed by exocytosis, by budding directly from the plasma membrane. Many viruses precisely trigger the timing of apoptosis to coincide with the completion of virus assembly. Herpesvirus capsids are enveloped inside the cell and use the normal protein secretory pathway for egress. Virions bud out of the cell, acquiring host plasma membrane and some host cell surface proteins. Influenza virus: disease: influenza, route of transmission: respiratory route, direct person-to-person contact transmission or via aerosols, target cells: epithelial cells of respiratory tract and alveolar macrophages, cell receptor: sialic acid (bound by hemagglutinin and cleaved by. Tetherin: a host restriction factor that inhibits the release of retrovirus release and is antagonized by vpu.