BIOL 2900 Lecture Notes - Lecture 12: Rna-Dependent Rna Polymerase, Influenza A Virus Subtype H1N1, Influenza Pandemic
29 Sep 2017
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Document Summary
Transmission: person to person, via respiratory droplets (most cases, sneezing, coughing, up to 1m virions per droplet, direct contact (kids, seasonal. 15th century italian scholars described the virus as a disease influenced by the stars : but also a pandemic (ex. 1918 spanish flu) killed ~50m worldwide; decreased life expectancy (because most people killed were young adults) Influenza virus: rna virus (consists of 8 rna segments, haemagglutinin (ha, attachment protein that recognizes receptor on cell, neuraminidase (na) proteins on the surface, enzyme that releases the virus from inside the cell. Tamiflu as a na inhibitor: virus cannot escape from infected cells, virus clumps (cannot infect new cells) How can we use the ha and na against the virus: make drugs to inhibit na (oseltamivir, make abs against ha and na. Antigenic changes of influenza: antigenic drift mutations (rna genome, antigenic shift reassortment (segmented genome)
