Question

Explain possible reasons for the prevalence of mitochondrial defects in embryos created by nuclear transfer cloning.

Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Terms can be used once, more than once, or not at all.

Help

Reset

oxidative phosphorylation

mitochondrial

nucleus

substrate phosphorylation

recipient

nuclear

mitochondria

donor

nuclei

____defects often involve processes of _____and/or other essential mitochondrial functions that are dependent not only on the mitochondrial genome, but also on the______ genome. When a______ genome is transferred, it may contain mutant genes that negatively influence_____ function that were compensated for in the original______ cells, but not in the _______ . In addition, enucleated eggs invariably contain both normal and defective_______ . When a ______genome is transferred to an enucleated egg, ______ defects may arise from an uncompensated defective______ genome, the heteroplasmic condition of the egg, or a combination of the two. A disease occurs when the ______ mutational load exceeds a tissue-specific threshold, which is generally low in highly metabolic tissues such as brain, heart, and muscle.