Explain why insertions and deletions often are more detrimental than substitutions.

Explain the concept of a frame shift.

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Related questions

Explain in details. When oncogenes are activated by mutation we most often find that the mutation is a substitution, while when tumor suppressor genes are mutated the common mutation is an insertion/deletion. Why is this? p53 is a tumor suppressor gene yet mutations in p53 found in cancers are more often substitutions not insertion/deletions and these mutations are dominant, loss-of-function, as opposed to recessive. We call this type of mutation âdominant negativeâ â explain what is meant by that terminology. Explain how the inactivation of p53 is different than for other tumor suppressors.

greendeer380

a. Which DNA mutation is more likely to have a detrimental effect on the protein it codes for: a 1 base pair deletion from the middle of the coding sequence of a gene, or a 9-base pair deletion from the same region of the gene? Explain why?

b. Would the outcome be different if the deletions happened within the geneâs intron? Explain why?

What is more likely to have a detrimental effect on the phenotype: a 1bp base pair deletion from the middle of the coding sequence of a gene, or a 9 base pair deletion from the very 5â region of the coding region of the gene? Fully explain why? Would the outcome be different if the deletions happened within the geneâs intron? Why?