1
answer
0
watching
210
views
24 Jan 2019
16. Sickle cell anemia is a genetic disorder resulting in an alternation of the structure and function of hemoglobin. Specifically, the amino acid valine replaces glutamate in a position located in the surface of the protein. Based on your knowledge of protein sequence answer the following:
a. At what level of protein structure does the amino acid substitution occur? Explain?
b. Provide a biochemical rationale for why this change in the sequence of hemoglobinâs beta chain results in red blood cells sickling. Your answer should include reference to structures of valine and glutamine shown above.
16. Sickle cell anemia is a genetic disorder resulting in an alternation of the structure and function of hemoglobin. Specifically, the amino acid valine replaces glutamate in a position located in the surface of the protein. Based on your knowledge of protein sequence answer the following:
a. At what level of protein structure does the amino acid substitution occur? Explain?
b. Provide a biochemical rationale for why this change in the sequence of hemoglobinâs beta chain results in red blood cells sickling. Your answer should include reference to structures of valine and glutamine shown above.
Trinidad TremblayLv2
25 Jan 2019