Some of the excess calories we consume are stored as fat glycogen. Excess storage can lead to obesity, which is one of the worldwide health issues in humans. Body weight is regulated by complex brain circuitry involving peripheral factors that primarily work in the brain. Please answer the following questions:
a) John is 30 years old. His height is 170cm and body weight is 88kg. Based on his BMI, is John is obese or not? (1.5 marks)
b) The ob/ob mutant mouse become obese due to mutation in the gene responsible for the production of a polypeptide hormone that affects the adipose tissue mass. What is the name of the hormone and where is produced in the body? (1.5 marks)
c) Pleases explain how the hormone regulates body weight, including the major brain site of its action (1 mark), its effect on appetite (2 marks) and the contribution of brown adipose tissue to the weight regulation. (2 marks)
d) In addition to this hormone, a peptide hormone produced by the gastrointestinal tract also contributes to regulating appetite and energy expenditure. The hormone was discovered by a Japanese group in 1990s. What is the name of the hormone? (0.5 mark) What is the main effect of this gut hormone on food intake, body weight and hunger signals? (1.5 marks)
Some of the excess calories we consume are stored as fat glycogen. Excess storage can lead to obesity, which is one of the worldwide health issues in humans. Body weight is regulated by complex brain circuitry involving peripheral factors that primarily work in the brain. Please answer the following questions:
a) John is 30 years old. His height is 170cm and body weight is 88kg. Based on his BMI, is John is obese or not? (1.5 marks)
b) The ob/ob mutant mouse become obese due to mutation in the gene responsible for the production of a polypeptide hormone that affects the adipose tissue mass. What is the name of the hormone and where is produced in the body? (1.5 marks)
c) Pleases explain how the hormone regulates body weight, including the major brain site of its action (1 mark), its effect on appetite (2 marks) and the contribution of brown adipose tissue to the weight regulation. (2 marks)
d) In addition to this hormone, a peptide hormone produced by the gastrointestinal tract also contributes to regulating appetite and energy expenditure. The hormone was discovered by a Japanese group in 1990s. What is the name of the hormone? (0.5 mark) What is the main effect of this gut hormone on food intake, body weight and hunger signals? (1.5 marks)
