Read the linked blog post about a recent study of a prostate cancer drug (http://goo.gl/O2GxAG) and answer a few questions based on the reading above.
1. The researchers tried to detect AR-V7 in the blood of men with advanced prostate cancer. Could they do this by sequencing DNA? What about by sequencing RNA? What about by detecting the protein? Donât worry about technical limitations; just tell me what is theoretically possible.
2. Healthy prostate cells do not produce AR-V7. Cancer cells tend to accumulate mutations more quickly than other cells. Given these two facts, it is tempting to propose that prostate cancer cells acquire a mutation that causes the production of AR-V7. Is this theory compatible with your understanding of how splicing works? Why or why not?
Read the linked blog post about a recent study of a prostate cancer drug (http://goo.gl/O2GxAG) and answer a few questions based on the reading above.
1. The researchers tried to detect AR-V7 in the blood of men with advanced prostate cancer. Could they do this by sequencing DNA? What about by sequencing RNA? What about by detecting the protein? Donât worry about technical limitations; just tell me what is theoretically possible.
2. Healthy prostate cells do not produce AR-V7. Cancer cells tend to accumulate mutations more quickly than other cells. Given these two facts, it is tempting to propose that prostate cancer cells acquire a mutation that causes the production of AR-V7. Is this theory compatible with your understanding of how splicing works? Why or why not?
