Log in
Biology
9
answers
0
watching
126
views
11 Jan 2018

Sickle cell anaemia induce to

(a) change of amino acid in a- chain of haemoglobin

(b) change of amino acid in b- chain of haemoglobin

(c) change of amino acid in both a and b chains of haemoglobin

(d) change of amino acid either a or b chains of haemoglobin.

Watch
9
answers
0
watching
126
views

For unlimited access to Homework Help, a Homework+ subscription is required.

Unlock all answers

Get 1 free homework help answer.
Already have an account? Log in
Share
Already have an account? Log in
Share
Already have an account? Log in
Share
Already have an account? Log in
Share
Already have an account? Log in
Share
Already have an account? Log in
Share
Already have an account? Log in
Share
18 May 2022
Already have an account? Log in
Share
Already have an account? Log in
Share

Related textbook solutions

Molecular Cell Biology
8 Edition,
Lodish
ISBN: 9781464183393
Biology: Science for Life with Physiology
6 Edition,
Belk
ISBN: 9780134555430
Concepts of Biology
OER Edition,
Openstax
ISBN: 9781938168116
Biology
2nd Edition, 2013
Openstax
ISBN: 9781947172517
Essentials of Biology
5 Edition,
Mader
ISBN: 9781259660269

Related questions

Police find a man unconscious in his car near Marion Shopping Centre. The car engine was running
with a hose taped to the exhaust carrying exhaust gases to the car's interior. The police take the
man to the FMC Emergency department where an arterial blood sample is taken and the man given
oxygen. Lack of oxygen may lead to changes in arterial blood gas results. In this case, carbon
monoxide, which is found in car exhaust, to various extents prevents oxygen from binding to
haemoglobin resulting in tissue hypoxia. Blood gas and co-oximetry measurements (the values of
oxyhemoglobin and carboxyhaemoglobin which show how much oxygen and carbon monoxide is bound to
haemoglobin, respectively) on the pre-treatment arterial blood give the following values:

RESULT UNITS REFERENCE RANGE
PO2 85 mmHg (80-100)
PCO2 30 mmHg (35-45)
HCO3- 18 mmol/L (21-28)
pH 7.31
(7.35-7.45)
Total
Haemoglobin 151 g/L
(130-175)
Oxyhaemoglobin 57%
(94-100%)
Carboxy-
haemoglobin 40%
(<2%, non-smoker)

a) Briefly explain the likely reason for this man’s unconsciousness. (1 mark)
b) Explain why his blood pH is below the normal range. Outline any relevant metabolic events and
indicate why these occur in this situation. (4 marks)
c) suggest explanation for the low PCO2 and HCO3- levels observed,
outlining any relevant mechanism(s). (5 marks)

9. Replacement of an A by a T in a region of the human gene for the B chain of hemoglobin is associated with sickle-cell anemia:

Normal: 5′-ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3′

Sickle cell: 5′-ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3′

(a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA?

(b) What is the amino acid sequence in this part of the Bpolypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin?

(c) Why might this amino acid substitution make a difference in protein structure?

Sickle cell anemia is caused by a mutation in a single amino acid in the hemoglobin chain. A glutamate is mutated to valine. What would be the effect of such a change?

Weekly leaderboard

Home
Homework Help 3,900,000
Biology 460,000
Start filling in the gaps now
Log in