For Leighâs Disease answer the following:

Describe the symptoms/outcomes of the disorder.

Identify the organelle that is affected.

Discuss the normal function of this organelle and how its function is disrupted.

What conclusions can you draw about the importance of this organelle in the cell?

Based on what you have learned about cell structure, predict how a cell from this disorder would look like under the microscope.

Based on the cell biology, what options do you have to treat the disorder?

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Keith LeannonLv2

11 Jul 2018

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In order to understand how cells function, we often have to use analogies to everyday items or processes to explain the jobs of the various organelles. In this assignment, we're asking you to determine which everyday items that you can find around the house (from your kitchen/desk drawers, backpack, a recycling bin, food, etc.) to represent the organelles inside a cell, and to assemble those items into a 3-dimensional representation of a eukaryotic (plant or animal) cell. Think about how the items you're using can best represent the various parts of the cells and their functions. For example, what does the mitochondria do? What household item do you have that is analogous, or could represent that function?

Note that the items that you find may or may not visually resemble their cellular counterparts. It's fine if they don't - weâre looking for you to demonstrate to us that you know what the various organelles do, and that you can think creatively about what objects fill that role in your house or in your life. Therefore, your finished "model" may not look much (or at all) like the diagram of a cell from your textbook! However, if the spatial organization of organelles is important (e.g. if one type of organelle is always located next to another), we do expect to see that reflected in your model.

Your model will need to include:

A picture (or pictures) of your model. The picture(s) must contain your name written on a piece of paper next to your model. If you'd like, include a picture of yourself with your model. (A cell-fie!)

Proper identification of the cell (is it a plant or animal cell)?

For each organelle/structure:

Correct labeling/identification of the structure in your image/video

A description of the organelle's function, which should be in YOUR OWN WORDS, not copied from the book, lectures, or other sites.

A justification for why the object that you chose to represent each organelle is a good analogy for that organelle's function.

Attention to quality and creativity â which will weigh into the overall evaluation.

You can do this in a text document, a powerpoint presentation, or a short video in which you verbally explain your model (be sure to include your name in the video!). Note that you will NOT receive credit for a drawing of a cell or a collage or collection of images found online. Any images you submit must be completely original and made by you. Your name should be in any document and/or picture you submit. Submissions without names will receive reduced credit.

This is NOT intended to be a burdensome exercise, nor should you need to purchase any materials to complete this assignment - I would like for it to be a fun way for you to practice working with the different types of organelles and their structures and functions, and to think creatively about the materials you have on hand.

greenwallaby197

1. Before bringing a new drug to the marketplace, extensivetesting is done on the drug by administering the drug to largenumbers of individuals. Explain the importance of the scientificmethod, sample size, controls and variable in the drug evaluationprocess.

2. List the four "large molecules of life." Identify theircomposition and structure, and describe one function that each ofthem performs in the cell.

3. How can you explain the occurrence of birth defects (causedby altered genes) in children and grandchildren of WWII atomic bombvictims, when the victims themselves were only mildly affected?

4. During the past 50 years, more than 200 species of insectsthat attack crop plants have become highly resistant to DDT andother pesticides. Based on what you have learned in this classregarding evolution, explain the rapid and widespread evolution ofresistance. Now that DDT has been banned in the US, what do youexpect to happen to levels of resistance to DDT among insectpopulations?

5. Water is crucial for life as we know it. One of the mostimportant characteristics of water is its ability to act as asolvent. Explain why water is such a good solvent for polar andcharged molecules.

6. Describe feeding relationships and energy flow in anecosystem, starting from producers. Use concepts such as trophiclevels, food chains, food webs, ecological pyramids.

7. Man has contributed significantly to the many environmentalproblems of the world including loss of biodiversity. Describe howthis particular problem can be solved.

8. Describe in your own words how antibiotic resistance comesabout.

9. Compare and contrast photosynthesis and respiration in termsof the organisms involved; the reactants; the type of energyprocess; and the organelles involved

10. Cystic fibrosis is a recessive genetic disorder. Thedisorder allele, which we will call a, is located on an autosome.What are the chances that parents with each of the followinggenotypes will have a child with this disorder? Show all yourworking for each.

aa x Aa
Aa x Aa
AA x aa
Aa x AA

11. Your friend explains to youthat her father has hemophilia, a genetic disorder that affects theprocess of blood clotting, so that his blood does not clot; but hermother does not, have it, she is healthy as far as this disorder isconcerned.

Knowing that the inheritance pattern for this disorder issex-linked, explain to your friend why it is more common for malesto inherit a sex-linked trait.
Using punnet square, indicate the probability that a brother ofyour friend would have hemophilia, assuming that her mother carriestwo functional copies of the gene involved in this sex-linkedrecessive disorder. Explain your answers fully.

apricotant790

You are a researcher working on a treatment for Hutchinson-Gilford progeria syndrome, an extremely rare genetic disorder that causes accelerated aging in children. Children with progeria generally appear healthy at birth but soon start growing more slowly than other children and lose their hair. Additional symptoms include stiffness of joints, heart problems, and stroke. These children typically die of heart disease at an average age of 13 years.

Progeria is caused by a mutation in a single gene, called lamin A. Scientists have identified over 1,400 mutations in the lamin A gene that result in changes in transcription, RNA splicing, and/or protein production. Lamin A codes for a protein required for the structural support of the nuclear envelope in cells. Without a functional protein, the nuclear envelope becomes unstable, eventually damaging the nucleus and causing cells to die.

Based on what you learned in this Click & Learn, propose a genetic medicine strategy you could develop to treat patients with progeria. Describe which step in gene expression you might target and why you would target that step, the intervention tool you would use, and explain how this strategy would treat the disease