Consider each of the pairs of mutational events and decide which of each pair would likely have the greatest effect on an organism. Describe the effect of each and indicating which would have the greatest effect and your reasoning.
A) Substitution in the first nucleotide of a codon OR substitution in the third nucleotide of a codon
B) Deletion of six nucleotides in the coding region OR deletion of two nucleotides in the coding
region
C) Mutation in the intron of a gene OR mutation in the promoter of a gene
D) Name one other location (not mentioned above) that a mutation could occur that could affect
the protein product and explain how the mutation would have an effect.
Consider each of the pairs of mutational events and decide which of each pair would likely have the greatest effect on an organism. Describe the effect of each and indicating which would have the greatest effect and your reasoning.
A) Substitution in the first nucleotide of a codon OR substitution in the third nucleotide of a codon
B) Deletion of six nucleotides in the coding region OR deletion of two nucleotides in the coding
region
C) Mutation in the intron of a gene OR mutation in the promoter of a gene
D) Name one other location (not mentioned above) that a mutation could occur that could affect
the protein product and explain how the mutation would have an effect.
Related textbook solutions
Related questions
A mutation has resulted in changes to both the size (number of amino acids) and the amino acid composition of the protein encoded by a gene. This mutation is most likely a (an) ---------.
| A. | Deletion of the promoter | |
| B. | Insertion or deletion of a base pair in an exon | |
| C. | Single missense mutation in the transcription region | |
| D. | A base substitution, which has changed the start codon to 5'ACG3' | |
| E. | Insertion or deletion of a base in the middle of an intron |
Part B
Think about the DNA coding sequence of a gene. If an A were swapped for a T, what kind of mutation could it cause and why?
| a) It could cause a frameshift nonsense or frameshift missense mutation because it would change the reading frame of the codon triplet. | ||||||||||||||||||||||||||||
| b) It could cause a silent, missense, or nonsense mutation because those are the types that can be caused by a nucleotide-pair substitution like this one. | ||||||||||||||||||||||||||||
| c) It could cause a nonsense mutation because the sequence would no longer be the same, so the protein would be shorter and non-functional. | ||||||||||||||||||||||||||||
| d) It could cause a silent mutation because A and T are complementary to each other so it is not really a substitution mutation. Part C Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?
|
