Why is it likely that microbes evolved the production of antimicrobial compounds, considering the use of antibiotics in medicine is less than 100 years old?

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Reid WolffLv2

10 Sep 2018

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1))Why is it important for the CDC to put a great effort in to creating new antimicrobials and antibiotics?

2)How has the therapeutic treatment of microbes changed over time and how must we change to prevent microbes from becoming âsmarterâ?

3)Include in your answer something that you can do to prevent antimicrobial resistance.

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Some antibiotics administered to humans inhibit peptide formation in microbes. How were the antibiotics made to target the microbes and not the eukaryotic host?

a-		all of the choices are correct
B-		Peptide synthesis occurs faster in prokaryotes, hence antibiotics act faster in prokaryotes than eukaryotes.
		C- Prokaryotes have ribosomal subunits that differ from eukaryotes.
	D-	Prokaryotic gene expression is cytosolic rather than compartmentalized, as in eukaryotes, hence more accessible to antibiotics.

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18. Health care professionals are concerned over the rise in antibiotic resistant bacterial strains. Exposure to antibiotics presents a selective environment that favors the evolution of resistance in bacteria. Which lines of evidence suggest that antibiotic resistance evolved a long time ago in bacteria (pre-dating the use of antibiotics by humans)? How and why has antibiotic resistance evolved in bacteria prior to exposure to antibiotic use by humans? What role does exposure to modern antibiotics play in the evolution of antibiotic resistance genes and mechanisms? Based upon the study by Baym et al. 2016, how does the evolution of antibiotic resistance in different bacterial strains inform drug discovery and better design of antibiotics and antimicrobials for human pathogens?