Question

You are tracing the path of an endocytosed protein that is destined for degradation. In what compartments, and in what order, do you expect the protein to appear? Compartments: I. clathrin-coated vesicle; II. uncoated vesicle; III. RER; IV. lysosome; V. endosomal sorting compartment; VI. Golgi

I—II—III—IV

I—II—V—IV

III—VI—V—IV

IV—III—V—IV