Not sure how to use data bases wormbase.org and https://www.ncbi.nlm.nih.gov/homologene/?term

to find infomtion answered below about unc-22

Please be specific.

post question and give the answer and please be specific. thank you.

Where is it located in the C. elegans genome? o How many splice products does it encode? o What type of gene does the gene encode? What is its function? o What are the major domains? How do these domains relate to the function of the protein o Does it have a human homolog? How similar is it? If it does not have a specific homolog, does it belong to a class of protein that is conserved across animal species? o What phenotypes does your mutant allele have? Where is it expressed? What phenotypes does the human disease gene cause?

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Bunny GreenfelderLv2

22 Sep 2018

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Mutants and mutant genes, 5 points You are studying a gene in chickens named âbonelessâ, named after its mutant phenotype. The wild type boneless gene encodes a protein that is 400 amino acids long. When a chicken lacks a wild type copy of the gene (in other words, when both of its copies are the boneless mutant version), it grows as a jiggly blob with eyes floating on top.

(A) The wild type function of the boneless gene is most likely to make ________________.

(B)To detect where boneless is expressed during embryogenesis you decide to perform an in situ hybridization experiment with a fluorescently labeled probe. To make this probe, what would you use as the template? Circle your answer and explain in one sentence why your answer is the better of the two choices.

(1) genomic DNA of boneless, which includes 4 exons and 3 introns (2) cDNA of boneless

(C) Given the phenotype of boneless, what can you conclude about the kind of gene that boneless encodes: (circle the correct answer)

(1) it must be a transcription factor (e.g. like pax6) (2) it must be a receptor (e.g. like the insulin receptor) (3) it must encode a calcium channel protein for strong bones (4) it must encode a microRNA gene (5) it must encode a housekeeping gene (6) nothing can be concluded about what kind of product this gene encodes based its mutant phenotype

(D) Although flies do not have bones, you discover that flies have a homolog of boneless called âpuddleâ. What must be true about puddle?

(1) flies donât need bones, therefore they have a puddle gene (2) flies lack bones because they lack boneless (3) the puddle gene makes flies boneless (4) puddle and boneless are sequences that arose from a common ancestral gene

using NCBI please fully answers thanks

1. Consider the gene database

a) Find HSP10. What is the human gene symbol and ID?

b) What chromosome is it on?

c) What are some of its aliases?

d) How many records are protein coding?

e) How many records are for splice variants?

f) Is there a gene record for Hsp10 Drosophila Melanogaster?

g) What is its gene symbol?

2. Consider the gene record

a) How many exons are there in HSP 10?

b) How many tissues is it known to be expressed in?

c) Reconfigure the viewer for epigenetic tracks (NCBI recommended). What are the first three tissues listed for CpG islands (CG rich, associated with transcription initiation?)

d) How many references into gene function (GeneRIFs) are there?

e) How many ârelated articlesâ are there about the HSP10 when searching PubMed directly? f) How many articles does PubMed say there are about gene function (gene sensor box?)

a. Download a nucleotide sequence from GenBank for a gene of interest. What gene did you download? Was the sequence published? Where, when, and by whom? What format is your nucleotide sequence in? Why is this gene of interest?

b. Perform a BLAST search with your DNA sequence. What does it match to (show the top 10 hits)? Are they from the same study or different studies? Is your sequence protein coding or not? What is the E-value of hit number 10 compared to hit number 1? What is an E-value?

c. Produce a pdf file with a short fragment (no more than 500 bps) of your sequence and the top 5 hits from your BLAST search showing them in FASTA format plus hits from at least 3 different species. What species are included in your data? List the taxonomic hierarchy of these species?

d. How many characters are in your FASTA file? How much space would you need to store a FASTA file of a human genome? A bacterial genome? A viral genome? How did you calculate this?

e. Translate the following sequence to amino acids (assuming the reading frame starts at the first letter):

ccgtcgtagc accgagcctc agcaccacga aagagattga agtagttcct cggaaagttc ttcgactctt ccttgaaaca tgtcttcctg gagcaaccaa cctgccatgg atgattatgg

What does this sequence encode? From what organism does this sequence come? What is the function of this gene? What are the proportions of polar, non-polar, and charged amino acids (attach a link to or copy of the resource you used to help you determine this)?