answer

watching

views

16 May 2019

Class: Microbiology

If a splinter of wood were to enter the skin and introduce microorganisms to the site, what specific early and late events of inflammation would respond to that newly infected tissue? Describe the sequence of signs and symptoms, vascular and tissue events, and cells and mediators involved.

answer

watching

678

views

For unlimited access to Homework Help, a Homework+ subscription is required.

You have 0 free answers left.
Get unlimited access to 3.8 million step-by-step answers.

Get unlimited access

Already have an account? Log in

Jarrod RobelLv2

17 May 2019

Unlock all answers

Get 1 free homework help answer.

Already have an account? Log in

Related questions

1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively beneficial response? Explain 2 pts

2. You are a physician and your patient has had a heart attack resulting in decreased blood flow to the heart tissue. Once blood flow is reestablished, what might be a major concern? 2pts

3. One of the first steps in inflammation is the development of increased adhesiveness of neutrophils to the endothelium cells of venules. How does this occur? Give details 3 pts

4. What approach might stop the P- and E-selectin-mediated step in inflammation, thus blocking the process? 2pts

5. What sequence of events is triggered by the initial adhesion of neutrophils? 2pts

6. For no known reason, a person is found to make autoimmune antibodies against the ?2 subunit of leukocyte integrins. What symptoms, if any, is s/he likely to exhibit? (2pts each)

How might leukocyte adhesion deficiency be treated?

How might antibodies against the ?2 subunit of integrins prove useful medically?

7. Cancer cells from a person suffering from malignant melanoma are analyzed and found to have an elevated ability to bind to laminin; they also secrete much higher than normal levels of a certain proteolytic enzyme activity. How would these differences from normal, control cells promote metastasis of these cancer cells? Explain 4 pts

8. Why would cells that express less E-cadherin be more likely to become malignant and give rise to epithelial cell tumors? Explain 3 pts

9. What would happen if you were able to inject the gene for ?5?1 integrin (a fibronectin receptor) into some tumor cells in such a way that it was expressed extremely efficiently? Explain 3pts

rubyeel26

Overview

How do you study pathophysiology? You have observed a case, and you have read many articles on topics related to how our body adapts to environmental toxins on a cellular level. Now you are going to go deeper in your observations to build your report.

Instructions

In at least 375 words, or 1.5 double-spaced pages, prepare a case report that addresses the following:

Based on the case study provided, respond to the following questions:

Identify and differentiate the symptoms from the signs in this patient.

What is the personal and social history of our patient?

What is the family history?

What results do you expect to find in the tests ordered?

What are some complications the patient is suffering now?

In regard to the patient's mother's breast cancer:

What are the four mechanisms of cellular adaptation? Explain.

What is the general classification of neoplasms according to their tissue of origin?

How would sickle cell anemia induce ischemia? What are the differences between ischemia and necrosis?

What are the differences between sickle cell anemia and leukemia? Compare their pathophysiology, symptoms, signs, and lab results.

All references must be cited using APA Style format.

Case Study:

Personal Information

Name: Mr. Peter Smith

Age: 45 years old

Gender: Male

Description

Mr. Peter Smith came to the medical office complaining of fatigue, asthenia, headaches, and generalized abdominal pain. Our patient tells us that he has had a high fever, but he did not take his temperature. The patient has had previous episodes of abdominal pain and arthralgia. Also, he was diagnosed with sickle cell anemia when he was a child. His father suffers from sickle cell anemia, diabetes mellitus, and essential hypertension. Our patientâs mother had a right radical mastectomy due to breast cancer a few years ago, and she suffers from sickle cell anemia, like Mr. Smith and his father. There is no other remarkable pathologic family history.

Mr. Smith drinks alcohol at least once per month and smoke cigarettes. He has no history of drug addiction. He is allergic to penicillin and iodine.

On physical we found:

Remarkable Signs on Physical Regions

Abdomen: Distended and painful on palpation, mostly on the left upper quadrant. Splenomegaly.

SOMA: Joint pain

Remarkable Signs on Physical by Systems

Integumentary system: Yellowish skin and pale nail beds. Superficial crater-like skin lesion on the right medial ankle area. An erythematous area accompanied by edema, purulent secretion, and heat surrounds the lesion.

Respiratory system: Tachypnea

Cardiovascular system: Tachycardia

Lab Tests

Complete blood count (CBC)

Hemoglobin electrophoresis

Abdominal ultrasound

EKG

Supporting Material

In order to understand Mr. Smith's case, we need to investigate the primary concepts of homeostasis at a cellular level and explore specific conditions when homeostasis is not present. How does our body adapt to environmental toxins? We will explore this question by looking at specific outcomes when there are deviations from homeostasis in three specific areas:

Cellular adaption and neoplasia

Infection, immunity, and inflammation

Hematological disorders

graygnu134