Part 1 Answer the following questions:
A). Typical patients with SCN present very early in life, with recurrent, severe bacterial infections that involved the skin, umbilical stump soft tissues, and lungs, with sepsis. Knowing the mechanism of action of neutrophils, describe why these are the typical characteristics, and why invasive fungal infections are of concern as well.
B) How might one differentiate between increased peripheral destruction of neutrophils and decreased production in the bone marrow as a cause of neutropenia.
C). Michael was diagnosed with acute myeloid leukemia, or cancer of myeloid progenitor cells from the bone marrow. Why was Michael at an increased risk of developing acute myeloid leukemia with a severe congenital neutropenia diagnosis?
Part 1 Answer the following questions:
A). Typical patients with SCN present very early in life, with recurrent, severe bacterial infections that involved the skin, umbilical stump soft tissues, and lungs, with sepsis. Knowing the mechanism of action of neutrophils, describe why these are the typical characteristics, and why invasive fungal infections are of concern as well.
B) How might one differentiate between increased peripheral destruction of neutrophils and decreased production in the bone marrow as a cause of neutropenia.
C). Michael was diagnosed with acute myeloid leukemia, or cancer of myeloid progenitor cells from the bone marrow. Why was Michael at an increased risk of developing acute myeloid leukemia with a severe congenital neutropenia diagnosis?
