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12 Jun 2019

Immunology Questions:

1. List and describe briefly the means of antibody diversity in naïve B cells (6 marks)

2. What is allelic exclusion and why is it important? (5 Marks)

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Keith Leannon
Keith LeannonLv2
14 Jun 2019

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Related questions

Hello this is an immunology question.

1. List the five classes of antibody heavy chains and provide one function for each. (10 marks)

2. A gram-negative bacterium is present in the blood of a host. List and briefly describe the three ways that the alternative pathway of complement could be activated.

For each of the following, identify the antibody or antibodies (if more than one) that meet each of the following criteria. Briefly (about one sentence or less) answer the follow-up question.

f)________ Used to prevent Rh- moms from being sensitized against an Rh+ baby. Briefly explain how this type of hypersensitive reaction could kill subsequent babies.

g)________ Found on the surface of a naïve B cell. What is a “naïve” B cell?

h)________ Responsible for the allergic response What happens during the two exposures required for the allergic response? (>1 sentence is OK)

i)________ Used in artificial passive immunizations What is the difference between “active” and “passive” immunity? State some examples

For each of the following, identify the antibody or antibodies (if more than one) that meet each of the following criteria. Briefly (about one sentence or less) answer the follow-up question.

a)________ Only antibody formed in the absence of TH-B cell interaction (T-independent pathway). What types of antigen allow this mechanism of B cell activation? b)________ Able to activate the complement cascade. What are three consequences of complement activation?

c)________ Able to initiate ADCC. What happens during ADCC?

d)________ Able to opsonize a pathogen. What is another opsonin that we talked about in Bio 221?

e)________ Main antibody secreted across mucosal surfaces. How do bacteria that use this portal of entry prevent this antibody from finding them?

f)________ Used to prevent Rh- moms from being sensitized against an Rh+ baby. Briefly explain how this type of hypersensitive reaction could kill subsequent babies.

g)________ Found on the surface of a naïve B cell. What is a “naïve” B cell?

h)________ Responsible for the allergic response What happens during the two exposures required for the allergic response? (>1 sentence is OK)

i)________ Used in artificial passive immunizations What is the difference between “active” and “passive” immunity? State some examples.

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