Question

You need to determine which degradable material to use as a tissue engineering scaffold
for repair of a critical-sized bone defect. (A critical-size defect is one that would not heal
unaided). You are planning to seed the scaffold with cells then implant it into the defect.
While the cells proliferate and generate bone, the scaffold will degrade and create void space
into which the new tissue may grow. What degradation method would you prefer for this
scaffold material and why? (hydrolytic vs. enzymatic degradation, bulk vs. surface
degradation)