Key: SD, standard diet; LF, low fat diet; KG, high fat (carbohydrate restricted-no carbs); HF mix, high fat + high carbohydrate âWestern Dietâ. BHB-CoA, beta-hydroxybutyryl-CoA; AcAc-CoA, acetoacetatoyl-CoA. Data are from livers (post absorptive) collected from rats fed the diets for three weeks.
a)Which major lipid pathway (s) do these intermediates reflect
Panel A._____________________________
Panel C._______________________________
b) What is the key enzyme (rate limiting step) for fatty acid synthesis ?________________________
c) How is this enzyme (in Q1 b) regulated in the fed vs fasted state in Liver?
What are the major differences in the regulation beta-oxidation in Muscle compared to liver?
Discuss prevention of futile cycles between fatty acid synthesis and beta-oxidation in liver and include transporter system (4 key regulatory steps & regulation) between cytosol and mitochondria.
Key: SD, standard diet; LF, low fat diet; KG, high fat (carbohydrate restricted-no carbs); HF mix, high fat + high carbohydrate âWestern Dietâ. BHB-CoA, beta-hydroxybutyryl-CoA; AcAc-CoA, acetoacetatoyl-CoA. Data are from livers (post absorptive) collected from rats fed the diets for three weeks.
a)Which major lipid pathway (s) do these intermediates reflect
Panel A._____________________________
Panel C._______________________________
b) What is the key enzyme (rate limiting step) for fatty acid synthesis ?________________________
c) How is this enzyme (in Q1 b) regulated in the fed vs fasted state in Liver?
What are the major differences in the regulation beta-oxidation in Muscle compared to liver?
Discuss prevention of futile cycles between fatty acid synthesis and beta-oxidation in liver and include transporter system (4 key regulatory steps & regulation) between cytosol and mitochondria.
