Consider a single locus with three alleles: A1, A2, and A3.
1) Write down all of the diploid genotypes possible at this locus.
2) Derive the equation for the frequency of allele A1 as a function of the genotype frequencies.
Consider the following two datasets:
At the M locus:
In a study of 1000 adults, the following genotype numbers were found:
M1M1 - 213 individuals
M1M2 - 489 individuals
M2M2 - 298 individuals
At the S locus:
In a study of 4555 adults, the following genotype numbers were found:
S1S1 - 3564 individuals
S1S2 - 979 individuals
S2S2 - 12 individuals
Assignment: For both loci
Calculate the frequency of the alleles.
Calculate expected number of each genotype if the population were in Hardy-Weinberg equilibrium.
Identify which locus most clearly violates at least one of the H-W assumptions
Consider a single locus with three alleles: A1, A2, and A3.
1) Write down all of the diploid genotypes possible at this locus.
2) Derive the equation for the frequency of allele A1 as a function of the genotype frequencies.
Consider the following two datasets:
At the M locus:
In a study of 1000 adults, the following genotype numbers were found:
M1M1 - 213 individuals
M1M2 - 489 individuals
M2M2 - 298 individuals
At the S locus:
In a study of 4555 adults, the following genotype numbers were found:
S1S1 - 3564 individuals
S1S2 - 979 individuals
S2S2 - 12 individuals
Assignment: For both loci
Calculate the frequency of the alleles.
Calculate expected number of each genotype if the population were in Hardy-Weinberg equilibrium.
Identify which locus most clearly violates at least one of the H-W assumptions
