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23 Aug 2019

ANS: Which type of cholinergic receptor responds to Ach binding by opening Na+ channels immediately? Which type responds by causing longer-term changes in ion permeability? Where would I find each of those cholinergic receptor types? g) What are the subdivisions of adrenergic receptors? h) What effectors are served only by the sympathetic division?

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Jarrod RobelLv2

25 Aug 2019

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Related questions

Tetraethylammonium (TEA) is a drug that blocks voltage-gated potassium channels. What effect would this have on an action potential?

(a)Prevent the rising phase

(b)Prevent the cell from reaching the threshold to trigger an action potential

(c)Prevent or prolong the falling phase

(d)None of the above

The hyperpolarization phase of the action potential is due to:

(a)The opening of voltage-gated Cl- channels

(b)Prolonged opening of voltage gated K+ channels

(c)The closure of resting Na+ channels

(d)Rapid inactivation of voltage-gated K+ channels

The period when it is difficult to initiate another action potential for several milliseconds due to voltage-gated sodium channel inactivation is referred to as the:

(a)Relative refractory period

(b)Absolute refractory period

(c)Resting period

(d)Hyperpolarization period

In the human central nervous system, Gap junctions are found:

(a)Only between neurons

(b)Only between astrocytes

(c)In both neurons and astrocytes

(d)In all cells

Small molecule transmitters such as acetylcholine are synthesized in:

(a)The nerve terminal

B) The cell body and transported to the nerve terminal

C) Synaptic vesicles

D) Endoplasmic reticulum

Prior to Otto Loewiâs classical experiment, which of the following was not known:

(a)stimulation of the vagus nerve slows the heart

(b)extracts of frog heart, made following vagal nerve stimulation, slow the heart

(c)some acetylcholine effects are similar to those produced by muscarine

(d)vagal nerve stimulation releases a substance which slows the heart

Which of the following is most important in determining if neurotransmission is excitatory or inhibitory?

(a)The structure of the synapse

(b)The neurotransmitter released by the presynaptic neuron

(c)The neurotransmitter receptor

(d)The strength of the stimulus

Benzodiazepines such as Valium allosterically regulate GABA receptors by:

(a)Binding at receptor sites other than the transmitter binding site

(b)Binding at the transmitter (GABA) binding site on the receptor

(c)Blocking the action of the endogenous transmitter

(d)Mimicking the action of the endogenous transmitter

GABA-A receptors are ligand-gated Cl- channels. The equilibrium potential of Cl- is -65 mV. At the neuronal resting membrane potential of -65 mV, GABA binding to the GABA-A receptor would result in the opening the Cl- channel, resulting in:

(a)no net flow of Cl- ions

(b)Cl- inflow and hyperpolarization

(c)Cl- outflow and depolarization

(d)Cl- outflow and hyperpolarization

At the mammalian neuromuscular junction, the released neurotransmitter acts on:

(a)muscarinic receptors

(b)nicotinic receptors

(c)adrenergic receptors

(d)Beta receptors

Neurotransmitters are packaged into synaptic vesicles by:

(a)endocytosis following transmitter release

(b)presynaptic membrane transporters

(c)vesicular transporters

(d)all of the above

. Which of the following are NOT types of ion channels?

Voltage-gated

(a)Ligand-gated

(b)G protein coupled receptor (GPCR)-gated

(c)Leak channels

(d)NONE of the above

NMDA receptors are unique in that their ion channel is:

(a)Ligand-gated

(b)Voltage-gated

(c)Ligand- and voltage-gated ion channels

(d)GPCR-gated

. Which of the following is INCORRECT regarding Catecholamine neurotransmitters

(a)Includes Dopamine, Norepinerphrine, and Epinephrine

(b)Contain a Catechol Ring

(c)Synthesized from Tryptophan

(d)Are produced by neurons whose cell bodies are located in the upper brainstem

The largest and most diverse group of receptors in eukaryotes is:

(a)Ligand gated receptors

(b)Glutamate receptors

(c)G-Protein coupled receptors

(d)Allosteric receptors

The most abundant G-protein coupled receptor in the brain is:

(a)Glutamate receptors

(b)Acetylcholine receptors

(c)Cannabinoid receptors

(d)Dopamine receptors

Which of the following drugs DOES NOT block voltage-gated Na+ channels

(a)Lidocaine

(b)Riluzole

(c)Reserpine

(d)Tetrodotoxin

Sarin, a nerve gas, exerts its toxicity by:

(a)blocking nicotinic receptors

(b)inhibiting choline acetyltransferase

(c)inhibiting acetylcholinesterase

(d)inhibiting voltage-gated Na+ channels

Botulinum Toxin (BoTox) interferes with transmitter release by:

(a)cleaving protein(s) involved in transmitter release

(b)blocking voltage-gated Ca2+ channels

(c)blocking voltage-gated Na+ channels

(d)blocking voltage-gated K+ channels

Atropine is:

(a)An agonist of the acetylcholine ionotropic receptor

(b)An antagonist of the acetylcholine ionotropic receptor

(c)An agonist of the acetylcholine metabotropic receptor

(d)An antagonist of the acetylcholine metabotropic receptor

Need help with biology questions:

1. To increase the excretion of an acidic drug, what would you do to the urine?

	A.	Make it more basic
	B.	None of the above
	C.	Make it neutral
	D.	Make it more acidic

2. G-Protein coupled receptors directly act on which of the following secondary messenger molecules:

	A.	cAMP
	B.	ATP
	C.	ADP
	D.	GTP
	E.	None of the above or more than one of the above

3. Drug A and Drug B both produce the same level of biological/physiological response. Drug A produces this effect with 100 mg/kg dose. Drug B produces this effect with 50 mg/kg dose. Which of the following is true?:

	A.	Drug B is more efficacious than Drug A. Both drugs are equally potent.
	B.	Drug A is more efficacious than Drug B. Both drugs are equally potent.
	C.	Drug A and B are equally efficacious. Drug A is more potent than Drug B.
	D.	Drug A and B are equally efficacious. Drug B is more potent than Drug A.

4. The stomach has a ______ pH, whereas the small intestines have a _______ pH. The colon has an approximately ___________ pH.

	A.	High; low; neutral
	B.	Low; high; neutral
	C.	Low; neutral; neutral
	D.	None of the above

5. Which receptor is most likely to reduce norepinephrine levels when activated?

	A.	alpha 2 adrenergic
	B.	alpha 1 adrenergic
	C.	dopamine D1 receptors

6. Which of the following statements are FALSE?

	A.	If the Vd of a drug is between 60 and 80 L the drug has likely distributed to the total body water of a 200 kg man.
	B.	In the enterohepatic system the activity of bacteria to remove conjugates from a drug in the gut will decrease the clearance of the drug.
	C.	Lipid drugs are more likely to be reabsorbed by the kidney from the urine.
	D.	A weak basic drug (pKa = 6) will be mostly ionized in urine of a pH= 3 and only the non- ionized drug will be eliminated.
	E.	The major conjugate in Phase 2 metabolism is glucuronide.

7. Isoproterenol (Î²-agonist) is a vasodilator that increases HR. What happens to systolic and diastolic pressures upon IV administration of isoproterenol?

	A.	â systolic; â diastolic
	B.	â systolic; â diastolic
	C.	â systolic; â diastolic
	D.	â systolic; â diastolic
	E.	None of the above

8. If you want to increase the blood concentration of a drug A, you can perform which of the following procedures:

	A.	Inhibit Drug A metabolism with Drug B
	B.	Enhance Drug A reabsorption from renal proximal tubule by changing ionization of Drug A with Drug B
	C.	Allow competition of Drug B with Drug A for active renal secretion processes
	D.	Increase the binding of Drug A to serum albumin
	E.	All of the above

9. Which of the following describes Phase I metabolism?

	A.	Inactive products are always produced in this phase.
	B.	Large molecules such as glucuronic acid are conjugated to drugs in this phase.
	C.	This phase may produce active metabolites from prodrugs.
	D.	This phase only occurs in the liver.

10. Which of the following is NOT an enzyme involved in the biosynthesis of biogenic amines?

	A.	Phenylethanolamine N-methyl Transferase
	B.	Dopamine Î²-hydroxylase
	C.	Tyrosine dehydroxylase
	D.	DOPA decarboxylase
	E.	All of the above

11. Why would an antibiotic at the same concentration be more active against bacteria in water than in serum or plasma? (Activity is measured in a test tube)

	A.	activity of the antibiotic is increased in water.
	B.	due to drug-protein interaction in serum
	C.	the antibiotic is more stable in water
	D.	all of the above
	E.	none of the above

12. Ion channels are targets for drugs. Which drug class targets Na+ channels?

	A.	Benzodiazepines
	B.	Beta blockers
	C.	Local anesthetics
	D.	Antihypertensive drugs (cardiac and smooth muscle)
	E.	Glibenclimide (diabetic drug)

13. _________________ not metabolized by catechol-O-methyltransferase (COMT).

	A.	Dopamine
	B.	Epinephrine
	C.	Phenylephrine
	D.	Norepinephrine
	E.	All of the above are metabolized by COMT.

Cells produced in the incision-healing process in the catâs abdomen would be ____ the other cells on her abdomen.

a) half the size of

b) haploid versions of

c) genetically different from

d) genetically identical to

During the same visit, your veterinarian recommended that your cat also receive a vaccination for feline distemper. This vaccine stimulated the catâs immune system to produce which one or more of the following?

a) antigens b) memory cells c) antibodies d) antibiotics e) both b & c

[1] The male elephant seal (l) is much larger than the female (r) of the species. Males spend very little time raising their young. You would correctly predict that the maleâs size is due primarily to _________ and that he is ___________in his mating habits.

a) natural selection; monogamous

b) sexual selection; polygamous

c) natural selection; polygamous

d) sexual selection; monogamous

[2] The Good Genes Hypothesis would account for which of the following characteristics of males that attract the most females?

a) Peacock tails, which prevent males from seeing behind them when they court

b) Sailfin molly, a dorsal-finned fish, which are enormous and easily spotted by predators

c) Guppy tailfins, which reduce their swimming speed.

d) Gray tree frogs, that call the longest and produce offspring that mature quickest

e) Fish that produce bright colors, yet have very weak immune systems.

[3] In mice, a recessive autosomal allele (o) results in obesity because the mice are unable to produce the hormone leptin from their fat cells.Normal mice with the dominant allele (O) do produce leptin. Homozygous recessive (oo) obese mice injected with leptin are observed to lose weight.

In a cross between two mice that are heterozygous for the obesity gene (Oo), you would predict which one of the following?

a) All the offspring will be obese.

b) All the offspring will be normal.

c) 50% of offspring will be able to produce leptin.

d) Obese offspring would eat less and burn more calories if injected with leptin.

e) Fat cells in obese mice release more leptin than those of their normal parents.

[4] A scientist discovers a new mutant mouse that he calls âChunkyâ because they are 80% heavier than normal mice. Which one or more of the following predictions would be correct?

a) Chunky mice could have the âddâ genotype.

b) Normal mice produce more thyroxin (thyroid hormone) than Chunky mice.

c) Glycolysis would occur more rapidly in Chunky mice than normal mice.

d) A protein that blocks leptin receptors would promote weight loss in all Chunky mice.

e) Both (a) & (b) are correct.

[5] When she was 6 months old, your cat was surgically altered so that they could not reproduce. This required a small incision into the catâs abdomen to remove the ovaries. This incision healed by a type of cell division called ______.

a) endocytosis b) meiosis c) mitosis d) exocytosis e) fusion

[6] Cells produced in the incision-healing process in the catâs abdomen would be ____ the other cells on her abdomen.

a) half the size of

b) haploid versions of

c) genetically different from

d) genetically identical to

[7] During the same visit, your veterinarian recommended that your cat also receive a vaccination for feline distemper. This vaccine stimulated the catâs immune system to produce which one or more of the following?

a) antigens b) memory cells c) antibodies d) antibiotics e) both b & c

How did the imagery of witches flying upon broomsticks originate? Historians have found evidence that some medieval European âdrug cultsâ included women who would prepare a potion by grinding up belladonna plants into an extract. Known as an anesthetic and muscle relaxant, this extract was applied using long sticks on the skin for rapid absorption into the bloodstream. The resulting symptoms included slowed breathing, dilated pupils, heavy eyelids, and a delirious sensation of flying.

[8] If one of these âwitchesâ wanted to counteract her shallow breathing and muscular weakness, you might recommend that she use â¦

a) botulinum toxin--an inhibitor of the release of acetylcholine.

b) calabar beans that contain an inhibitor of acetylcholinesterase.

c) a frog toxin that keeps the sodium ion (Na+) channels of the axon stuck opened.

d) curare, which blocks acetylcholine binding to post-synaptic muscle cells.

e) oubain, a plant toxin which inhibits the Na+/ K+ATPase pump.

After running around, a dog lies down to rest. Which of the following does not describe the flow of heat?

a. The dog loses heat by conduction to the warmer ground.
b. The dog loses heat by the evaporation through panting.
c. The dog loses heat by convection to the wind.
d. The dog gains heat by the radiation from the sun.
e. The dog generates heat by respiration.

What is the smallest number of DNA nucleotide sequence changes that must occur to cause a change in one amino acid in a particular protein?

a) 0 b) 1 c) 2 d) 3 e) 64