Two main classes of genes, oncogenes and tumor suppressor genes, are critical for cancer. Describe the types of mutations that result in these genes.

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Elin HesselLv2

6 Dec 2018

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There is a local biotechnology company who has decided to hire you for the summer. The main goal of this company is to develop drugs that inhibit the products of upregulated cancer genes.

A) Will your new drug target the products of tumor suppressor genes or oncogenes?

B)Explain why your proposed target is the right target. How could targeting the products of the other target be potentially harmful?

crimsonduck462

Explain in details. When oncogenes are activated by mutation we most often find that the mutation is a substitution, while when tumor suppressor genes are mutated the common mutation is an insertion/deletion. Why is this? p53 is a tumor suppressor gene yet mutations in p53 found in cancers are more often substitutions not insertion/deletions and these mutations are dominant, loss-of-function, as opposed to recessive. We call this type of mutation âdominant negativeâ â explain what is meant by that terminology. Explain how the inactivation of p53 is different than for other tumor suppressors.

greendeer380

Give two examples of tumour suppressor genes and twoexamples of oncogenes, describe their action, and indicate cancersin which they are inactivated.