-ANSWER EACH QUESTION IN 1 PARAGRAPH. EACH ANSWER CANNOT EXCEED MORE THAN HALF A PAGE.
-PROVIDE TWO REFERENCES FOR EACH ANSWER (NO WIKIPEDIA!). USE A CITATION FORMAT OF YOUR CHOICE AND BE CONSISTENT.
1. (a) Discuss the permeability of biological membranes as a function of hydrophilicity / lipophilicity of solute molecules.
(b) Discuss the permeability of biological membranes as a function of a solute molecule size.
(c) What is the approximate molecular weight above which the permeation of water-soluble substances by diffusion occurs at negligible rates?
(d) How do water-soluble molecules that are much larger than this cut-off enter and leave the cell?
2. The poison cyanide acts by binding irreversibly to one of the components of the electron transport chain, blocking its action. As a result, the entire electron transport process comes to a screeching halt and the cells lose 94% of their ATP-producing capacity. Considering the types of cellular activities that depend on energy expenditure, what would be the consequences of cyanide poisoning?
3. Briefly discuss gene therapy and describe 2 potential clinical applications
-ANSWER EACH QUESTION IN 1 PARAGRAPH. EACH ANSWER CANNOT EXCEED MORE THAN HALF A PAGE.
-PROVIDE TWO REFERENCES FOR EACH ANSWER (NO WIKIPEDIA!). USE A CITATION FORMAT OF YOUR CHOICE AND BE CONSISTENT.
1. (a) Discuss the permeability of biological membranes as a function of hydrophilicity / lipophilicity of solute molecules.
(b) Discuss the permeability of biological membranes as a function of a solute molecule size.
(c) What is the approximate molecular weight above which the permeation of water-soluble substances by diffusion occurs at negligible rates?
(d) How do water-soluble molecules that are much larger than this cut-off enter and leave the cell?
2. The poison cyanide acts by binding irreversibly to one of the components of the electron transport chain, blocking its action. As a result, the entire electron transport process comes to a screeching halt and the cells lose 94% of their ATP-producing capacity. Considering the types of cellular activities that depend on energy expenditure, what would be the consequences of cyanide poisoning?
3. Briefly discuss gene therapy and describe 2 potential clinical applications
