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Sickle-cell anemia is caused by a recessive mutation in the hemoglobin gene. However, heterozygote Individuals also show a small percentage of sickled red blood cells. What type of inheritance pattern in this example of? a) Incomplete dominance b) Polygenic inheritance c) Sex linked d) Chromosomal nondisjunction

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Related questions

Part 1 - Mendelian Genetics Review

Match the example with the type of inheritance.

A) Complete dominance B) Incomplete dominance C) Codominance

_______Pea shape in garden pea plants: The W gene encodes for an enzyme that synthesizes starch granules in peas. The w gene encodes for a dysfunctional enzyme that will not synthesize the starch granules. The presence of starch granules makes the seeds round, and the absence of the starch granules results in wrinkled seeds. Heterozygotes have only half as many starch granules, yet that is enough to make the seeds round.

_______Piebald (white) spotting in cats: Cats homozygous for the s allele do not have any white spots. Cats with the S allele are completely white. Cats that are heterozygous (Ss) are about 50% white.

________ Sickle-cell anemia in humans: Heterozygotes have one copy of the wild-type hemoglobin and one copy of the mutant hemoglobin. Phenotypically, heterozygotes have about half the number of sickled red blood cells as
homozygotes do.

Are the following genetic mutation positive for the 3 characteristics listed below - Phenylketonuria (PKU), Smith-Lemli-Opitz syndrome (SLOS), Alzheimer’s disease, Sickle cell anemia?

1. It is inherited (at least in some individuals or families) as a single-gene disorder (this means that a disorder where many cases are due to a mix of multiple contributing genes and environmental factors, such as heart disease or Alzheimer’s, could still be chosen if you focus on those instances with a single-gene cause)

2. It demonstrates at least one non-Mendelian characteristic (incomplete penetrance, variable expressivity, sex inflence, sex limited multiple alleles, or incomplete dominance) in its inheritance pattern

3. It is caused by mutations in a gene that has been identified and characterized.

Sickle cell anemia is a genetic disorder that is caused by a single nucleotide change in a single gene, the gene for beta hemoglobin. Individuals who are homozygous for this recessive allele have the disorder, which may result in abnormal hemoglobin, and thus abnormal red blood cell function. Investigate the molecular basis of sickle cell anemia and give specific examples of how the disorder could be diagnosed at the molecular, cellular, and organismal levels.

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