Identify and briefly describe three of the processes by which deamination of DNA-cytosine residues by AID could lead to mutagenesis.
Fill in the blanks.
The most likely pathway would involve deamination of________1_________ to _______2________ , with the U templating_____3_________ on the next round of synthesis. Another possibility is for_______4________ to create an abasic site after removing ________5_________created by deamination, with________6__________ then being inserted opposite that site during the________7_______ , before the ________8_______can be completed. A third possibility would be repair of the GâU mismatch by _________9__________ or _______10_________, giving an__________11______ pair that would replicate to give_________12___________ .
Word Bank: (each word can only be used once)
any base next round of replication U GâC AâU UNG NER mismatch repair repair process G A T GâU AâT
Identify and briefly describe three of the processes by which deamination of DNA-cytosine residues by AID could lead to mutagenesis.
Fill in the blanks.
The most likely pathway would involve deamination of________1_________ to _______2________ , with the U templating_____3_________ on the next round of synthesis. Another possibility is for_______4________ to create an abasic site after removing ________5_________created by deamination, with________6__________ then being inserted opposite that site during the________7_______ , before the ________8_______can be completed. A third possibility would be repair of the GâU mismatch by _________9__________ or _______10_________, giving an__________11______ pair that would replicate to give_________12___________ .
Word Bank: (each word can only be used once)
| any base | next round of replication | U | GâC | AâU | UNG | NER |
| mismatch repair | repair process | G | A | T | GâU | AâT |
