1. Which one of the following peptides will show the strongest absorbance of UV light at a wavelength of 280 nm? a. ESLALRIFPTV
b. YDQHHWRIYTS
c. HSIVYDGN
d. NQTRSTRHS
e. HNSLRHMTP
2. In a multiple sequence alignment, which of the following pairs or groups of amino acids would NOT be considered similar? a. E and D
b. F and P
c. I, L, and M
d. S and T
e. K and R
3. On a Ramachandran plot, which amino acid would show the largest range of Ï and Ï angles?
a. D
b. S
c. C
d. P
e. G
Thank you so much!
1. Which one of the following peptides will show the strongest absorbance of UV light at a wavelength of 280 nm? a. ESLALRIFPTV
b. YDQHHWRIYTS
c. HSIVYDGN
d. NQTRSTRHS
e. HNSLRHMTP
2. In a multiple sequence alignment, which of the following pairs or groups of amino acids would NOT be considered similar? a. E and D
b. F and P
c. I, L, and M
d. S and T
e. K and R
3. On a Ramachandran plot, which amino acid would show the largest range of Ï and Ï angles?
a. D
b. S
c. C
d. P
e. G
Thank you so much!
For unlimited access to Homework Help, a Homework+ subscription is required.
Related textbook solutions
Related questions
Protein Structure
a.Different function of proteins and examples:
b. Protein building blocks:
1. atomic composition of building block:
2. "parts" or "functional groups" of the building block:
c. Importance of side chain (R group):
d. Hydrophobic amino acids characteristics:
e. Hydrophilic amino acids characteristics:
f. Charged amino acids characteristics
Copy and complete the table below regarding the characteristics and which groups in the polypeptide interact together at each structural level of the protein.
| characteristics | groups interacting | ||
|---|---|---|---|
| Primary structure | |||
| Secondary structure | |||
| Tertiary structure | |||
| Quartenary structure |
Value: 2
Choose the correct statement(s). You may choose more than one answer.
[mark all correct answers]
a. Proteins are the building blocks of amino acids.
b. Enzymes are a type of protein.
c. Quartenary structure consists of two or more polypeptide chains interacting.
d. Amino acids are made of carbon, hydrogen, nitrogen and phosphorus.
e. The primary structure of a protein is formed due to the interaction of side groups.
Value: 3
Put the following statements regarding the structural levels of a protein formation in the correct order.
Below is a sequence of events. Place them in the order they should occur, number 1 being the first item. Select the step number from the drop down next to each item.
Items to order:
1. Individual amino acids are bonded together via peptide bonds.
2. Two or more polypeptide chains interact via bonds.
3. Hydrogen bonds form between neighboring amino acids within a polypeptide chain allowing the chain to coil or form pleated sheets.
4. Side groups (R) of the individual amino acids interact with each other allowing the protein to assume its three dimensional shape.
Value:4
Put the following statements regarding the structural levels of a protein formation in the correct order
| Individual amino acids are bonded together via peptide bonds. | 1 2 3 4 |
| Two or more polypeptide chains interact via bonds. | 1 2 3 4 |
| Hydrogen bonds form between neighboring amino acids within a polypeptide chain allowing the chain to coil or form pleated sheets. | 1 2 3 4 |
| Side groups (R) of the individual amino acids interact with each other allowing the protein to assume its three dimensional shape. | 1 2 3 4 |
Value: 5
Hydrophobic amino acids will be found _______________.
a. In the interior (inner core) of a protein, away from the watery environment.
b. in the interior of a plasma membrane.
c. Both A and B
d. Neither
Value: 6
A protein's function is defined by ____________.
a. enzymatic reactions
b. it's shape.
c. chain of nucleotides.
d. the presence of carbon and hydrogen.
Value: 7
Which of the following is NOT considered a protein function?
a. transport of substances across membrane
b. enzymatic reactions
c. provides structural support
d. carries genetic information
Instructions
BACKGROUND
The amino acid sequence for a protein that is associated with the onset of Huntington's Disease in humans is 582 amino acids long and is provided below. This disease is autosomal dominant and results in a prolonged degeneration of nerve cells in the brain.
INSTRUCTIONS
For this assignment, use any method you determine most feasible (i.e. programming in MATlab, R script, Crystal Ball, Witchcraft/Hocus Pocus, etc.) to decipher the amino acid composition of this protein and answer the 15 questions associated with this protein and its associated amino acid structure.
You will be calculating proportions (percentages - %) for this assignment. Calculate all proportions to 1 decimal place and make sure you have rounded up or down correctly. If unsure, use a spreadsheet program such as Excel to display your proportional calculations to 1 decimal place.
Spelling matters (Incorrect spelling will be graded as such - incorrect).
Huntington Disease Associated Protein Amino Acid Sequence
The first amino acid below ('m') represents the amino (NH3) terminus of this protein. The last amino acid in this sequence represents the carboxy (COOH) terminus and is the very last 'c' at the bottom of this protein sequence structure. The amino acids are numbered individually across the rows (left to right) beginning from the amino terminus (#1) to the carboxy terminus (#582).
| mvskreniat | hhlyqawdpv | pslspattga | lisheklllq | inperelgsm | syklgqvsih |
| svwlgnsitp | lreeewdeee | eeeadapaps | spptspvnsr | khragvdihs | csqfllelys |
| rwilpsssar | rtpailisev | vrsllvvsdl | fternqfelm | yvtltelrrv | hpsedeilaq |
| ylvpatckaa | avlgmdkava | epvsrllest | lrsshlpsrv | galhgilyvl | ecdllddtak |
| qlipvisdyl | lsnlkgiahc | vnihsqqhvl | vmcatafyli | enypldvgpe | fsasiiqmcg |
| vmlsgseest | psiiyhcalr | glerlllseq | lsrldaeslv | klsvdrvnvh | sphramaalg |
| lmltcmytgk | ekvspgrtsd | pnpaapdses | vivamervsv | lfdrirkgfp | cearvvaril |
| pqflddffpp | qdimnkvige | flsnqqpypq | fmatvvykvf | qtlhstgqss | mvrdwvmlsl |
| snftqrapva | matwslscff | vsastspwva | ailphvisrm | gkleqvdvnl | fclvatdfyr |
| hqieeeldrr | afqsvlevva | apgspyhrll | tclrnvhkvt | tc | CARBOXY TERMINUS |
I need these decoded in order to answer the following questions:
a.) What is the name of the least abundant amino acid in this protein and what proportion of the total amino acids in the protein does this individual amino acid represent?
b.) What is the proportion of essential amino acids included in this protein sequence?
c.)How many Tryptophan residues are present in this protein sequence?
d.) The amino acid sequence from residues 73-85 is represented by the amino acids EEEWDEEEEEEAD, how would you generally classify this small region of the protein
e.) Two amino acids are present in the same proportion in this protein, which two are those?
f.) How many positively charged amino acids are present in this protein?
g.)Which class of amino acids is the most abundant in this protein?
h.) What amino acid(s) is/are present at locations 572 and 582 in the Huntington Disease protein (Full Amino Acid Name(s))
i.) What type of structure could form between these amino acids that could help stabilize this protein's structure?
j.) How many valine residues are present in this protein?
k.)Which class of amino acids is least abundant in this protein?
l.) How may negatively charged amino acids are present in the Huntington disease protein?
m.) How many Aspartic Acid residues are present in this protein and what proportion do they represent of the total amino acids in this protein?
n.)Summed together, how many hydrophilic amino acid residues are present in this protein?
o.)What is the sequence of amino acids from positions 487-492 (First letters only)?
p.) How would you classify this area of the Huntington protein based on these amino acids?
No handwriting please and only answer if you are gonna complete all of them from 30-40. Thanks in advance and hope you are having a great day today.
Select the correct answer:
30. How would amino acids from the bloodstream move across a cell membrane?
| a. | diffusion | |
| b. | osmosis | |
| c. | facilitated diffusion | |
| d. | active transport | |
| e. | endocytosis |
31. Which of the following is not a greenhouse gas?
| a. | water vapor | |
| b. | carbon dioxide | |
| c. | gaseous nitrogen | |
| d. | methane | |
| e. | nitrous oxide |
32. The greenhouse effect is most similar to
| a. | heating up the air inside a car by parking it in the sun | |
| b. | warming the air for a hot-air balloon with a propone burner | |
| c. | burning kerosene in a heater to warm up the air inside a cold house | |
| d. | growing plants in your office to reduce indoor air pollution | |
| e. | cooking food with a charcoal grill |
33. Temperature is a measure of
| a. | the potential energy in a substance | |
| b. | how fast the molecules in a substance are moving | |
| c. | the energy lost from a substance to its surroundings | |
| d. | how much heat is being absorbed by a substance |
34. Fossil fuels include all the following EXCEPT
| a. | oil | |
| b. | coal | |
| c. | hydrogen gas | |
| d. | natural gas | |
| e. | gasoline |
35. On Earth,________is/are the largest reservoir of carbon dioxide and heat.
36. Chemical work within cells is powered by
| a. | NAD+ | |
| b. | NADPH | |
| c. | ADP | |
| d. | ATP |
38. Which of the following processes creates the most ATP per glucose molecule metabolized?
| a. | glycolysis | |
| b. | fermentation | |
| c. | photorespiration | |
| d. | aerobic cellular respiration | |
| e. | the light reactions of photosynthesis |
39. In cellular respiration,_______is produced during_______.
| a. | oxygen; the citric acid cycle | |
| b. | carbon dioxide; the citric acid cycle | |
| c. | oxygen; the light reactions | |
| d. | carbon dioxide; the light reactions |
40. Metabolic pathways that require oxygen are referred to as
| a. | aerobic | |
| b. | anaerobic | |
| c. | photosynthetic | |
| d. | fermentative |
