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Consider a deleterious recessive allele at a frequency of q =0.0016 in the population.
a. How many times more likely is the offspring of a cousin matingto suffer its effects (that is, to be homozygous for it) than is anoutbred individual?

b. Now do the same analysis for recessive alleles at lower (q =0.0005) and higher (q = 0.05) frequencies. For which kinds ofalleles does inbreeding most strongly increase the probability(absolutely, and relatively) of being affected by themutation?

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Tod Thiel
Tod ThielLv2
28 Sep 2019

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