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explain how a multipass transmembrane protein is inserted intothe ER membrane during translation

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Patrina Schowalter
Patrina SchowalterLv2
28 Sep 2019

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Related questions

I. ER Translocation of Secretory orTransmembrane Proteins:

1. During neural development,outgrowing nerve cell axons must interact with their cellularenvironment in order to determine correct organization andconnectivity. Cell adhesion molecules (CAMs) are prominentone passtransmembrane glycoproteins which mediate the signalingnecessary to ensure correct targeting of these nerve axons.

Question:

How is a cell adhesion transmembrane proteinsorted/translocated initially so that it will be inserted into theplasma membrane as a type I membrane protein?[Hint: Describethe specific steps that a type I transmembrane protein will gothrough in the RER for insertion into the membrane].

Describe how a newly synthesized integral protein (other than those of mitochondira and chloroplast) with a single transmembrane segement is inserted into a membrane?

During neural development, outgrowing nerve cell axons must interact with their cellular environment in order to determine correct organization and connectivity. Cell adhesion molecules (CAMs) are prominent one pass transmembrane glycoproteins that mediate the signaling necessary to ensure correct targeting of these nerve axons.

a) How is a cell adhesion transmembrane protein sorted/translocated initially so that it will be inserted into the plasma membrane as a type I membrane protein? [Hint: Describe the specific steps that a type I transmembrane protein will go through in the RER for insertion into the membrane].

b) The binding of cell surface receptor to its ligand is the 1st step in a signal transduction pathway which ultimately results in the activation of many cytoplasmic proteins in a step-wise fashion. Explain 2 reasons why this method of signaling is advantageous for a cell.

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