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RNA & the synthesis of Telomeres?

Hello! Can someone help me with the following question please? Thanks!

The enzyme telomerase is considered a reverse transcriptase, synthesizing DNA on an RNA template. What is the source of the RNA used in the synthesis of telomeres, and where is it located?

A) The RNA template is a small tRNA that binds tightly to the telomerase reverse transcriptase (TERT) to form the active telomerase holoenzyme

B) The RNA template is a small nuclear RNA that binds simultaneously to DNA and telomerase reverse transcriptase (TERT)

C) The RNA template is telomerase RNA, which is bound tightly to the telomerase reverse transcriptase (TERT) to form the active telomerase holoenzyme.

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Keith Leannon
Keith LeannonLv2
28 Sep 2019
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Related questions

True or false. *If a statement is false, cross out the one incorrect word in the sentence, then write the word on top of the incorrect word to make the statement correct.

-The ΔG of an unfavorable reaction is increased by syphoning away its product with a highly favorable reaction.

-All proteins share the same phosphate backbone that helps form secondary structure through non-covalent hydrogen bonds.

-Telomerase performs DNA synthesis using an RNA template.

-Highly condensed chromatin is called heterochromatin and is associated with lysine acetylation that leads to transcriptional splicing.

-In eukaryotes, mismatch repair of DNA polymerase errors uses methylation in the new strand to distinguish it from the old strand.

-Competitive inhibition requires that a ligand binds within the enzyme active site to prevent substrate binding.

Multiple choice.

1.Origins of replication...

A. occur at many sites on bacterial and human chromosomes

B. contain one replication fork each where the daughter stands are being sythesized

C. initiate replication in a uni-directional manner

D. result in bubbles opened by helicases

E. occur at one site per chromosome

2.Telomerase...

A. is important for the replication of circular chromosomes

B. is important for the replication of linear chromosomes

C. carries a template in the form of a DNA molecule

D. sythesizes RNA primers

E. both the 1st and 2nd option are correct

3.What are topoisomerases?

A.Enzymes that lay down an RNA primer during DNA synthesis.

B.The ends of the chromosomes.

C. Proteins that unwind DNA.

D. A strain of mice.

4.Which enzyme produces the first piece of nucleic acid synthesized in DNA replication?

A. Primase

B. DNA polymerase

C.ORC

D. DNA ligase

5. Which of the following does not contribute to the mutagenesis of our DNA?

A. alterations to bases (nucleotides) that change their hydrogen bonding characteristics

B. passing on of mismatched DNA into daughter cells

C. inefficiency of MutS to recognize errors in base pairing

D. DNA polymerase slipping during synthesis and creating insertions or deletions

E. DNA polymerase erroneously synthesizing DNA in the reverse direction during S phase

1. Which of the following is the correct sequence of events (from start to finish) in cellular fatty acid oxidation?

A. Fatty acid activationà carnitine shuttleà beta-oxidation

B. Beta-oxidationà carnitine shuttleà Fatty acid activation

C. Fatty acid activationà carnitine shuttleà beta-oxidation

D. Carnitine shuttleà Fatty acid activationà beta-oxidation

2. What reaction is catalyzed by lipoprotein lipase, or lipase?

A. Hydrolysis of TAGs into fatty acids and glycerol

B. Hydrolysis of TAGs into amino acids and glycerol

C. Hydrolysis of cholesterol in to fatty acid and water

D. Hydrolysis of cholesterol into acetyl-CoA

3. How do fatty acids of different carbon lengths cross into the mitochondrial matrix for oxidation?

A. Small FAs of 10 carbons or fewer can freely diffuse through the membrane

B. Large FAs are cleaved into two smaller units that are actively transported across the membrane

C. A membrane-bound transferase catalyzes the conversion of long-chain FAs and FA-carnitine esters, which are transported across the membrane via a specific carrier

D. The breakdown of large FAs starts outside the matrix, allowing for the smaller particles to pass easily through the membrane

4. How can any RNA nucleotide be easily distinguished from a DNA nucleotide?

A. RNA nucleotides have a unique phosphodiester bond linkage

B. RNA nucleotides have uracil nitrogenous bases

C. RNA nucleotides have an -OH on the 2’ carbon of the ribose

D. RNA nucleotides cannot be easily distinguished from DNA nucleotides

5. Which of the following statement is true concerning the sequence pTACGTAACGTA?

A. This is an RNA sequence

B. In order to have a more rigid structure in a double-stranded molecule, the sequence given would need more adenosine

C. If the complementary strand were present, the number of purines would be equal to the number of pyrimidines

D. The amount of purines is equal to the amount to pyrimidines

6. Complementary base pairing is considered which level of structure?

A. Secondary

B. Tertiary

C. Quaternary

D. Primary

7. Which of the following is/are required for the polymerization reaction catalyzed by DNA polymerase III?

I. RNA primer

II. DNA primer

III. RNA template

IV. DNA template

V. NTPs

VI. dNTPs

VII. Magnesium

VIII. Calcium

A. II, IV, V, and VII

B. II, IV, VI, and VII

C. I, IV, V, and VIII

D. I, IV, VI, and VII

8. DNA polymerase I, from E. coli, has three different catalytic sites. Which of the following is NOT one of them?

A. RNA-dependent RNA polymerase

B. RNA-dependent DNA polymerase

C. DNA-dependent RNA polymerase

D. DNA-dependent DNA polymerase

9. Eukaryotes solve the problem of replicating the ends of their linear chromosomes by:

A. Using a protein as primer

B. Enzyme activity that uses an RNA template and reverse transcription in a series of repeat cycles

C. All of the listed solution

D. Terminal redundancy whereby each end of the chromosome is duplicated allowing recombination

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