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1. What is heterozygosity? How does heterozygosity work and why it important in the body? Why is a loss of heterozygosity an important process in the development of cancer?

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Nestor Rutherford
Nestor RutherfordLv2
28 Sep 2019
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Related questions

1. Why do cancer cells need to have lost both pRB and p53?

2. What is the evidence that enzymes whichmaintain the integrity of the genome are important in preventingcancer?

3. Why is Lossof Heterozygosity an important process in the development ofcancer?

1. Inbreeding tends to increase the proportion of homozygous individuals in a population (i.e., individuals with two copies of the same allele).

A. True

B. False

2) The effective size of a population is:

A) The size of an idealized randomly-mating population that is not under selection and has the same heterozygosity as the actual population.

B)The size of an idealized randomly-mating population that has the same heterozygosity as the actual population, but does not lose heterozygosity over time.

C)The size of an idealized randomly-mating population losing homozygosity at the same rate as the actual population.

D) The size of an idealized randomly-mating population losing heterozygosity at the same rate as the actual population.

.

3) Which of the following tends to reduce the effective size of a population?

Check all that apply:

Increasing the census population size

An unbalanced sex ratio

Non-random mating

You genotype a C/T SNP from a sample of narwhals (Monodon monoceros) from the arctic at two locations, Canada and Siberia, and get the following genotype frequencies.

Canada

c-/c- 9

c+/c- 26

c+/c+ 30

Siberia

c-/c- 28

c+/c- 32

c+/c+ 15

A) What is the frequency of the c- allele in each population?

B) What fraction of heterozygosity is missing (FIS) in each population?

C) What is the average of the expected frequency of heterozygotes over all populations (HS)?

D) What is the average allele frequency over all populations?

E) What is the total expected heterozygosity frequency (HT)?

F) What is the fraction of heterozygosity missing due to differences in allele frequencies between populations (FST)?

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