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28 Sep 2019
(3 Points) For each of the genes (3 in total) listed above, indicate how HIF1α-mediated regulation might allow cells to better adapt to a hypoxic situation. (4 Points) In many cancer cell lines, PDH kinase (PDK) activity is increased. The result of this regulation is that pyruvate is directed towards a pathway other than the TCA cycle. Once again, using your excellent research skills, explain the reason cancer cells might direct pyruvate to an alterative pathway and what advantage this might provide to cancer cells.
(3 Points) For each of the genes (3 in total) listed above, indicate how HIF1α-mediated regulation might allow cells to better adapt to a hypoxic situation. (4 Points) In many cancer cell lines, PDH kinase (PDK) activity is increased. The result of this regulation is that pyruvate is directed towards a pathway other than the TCA cycle. Once again, using your excellent research skills, explain the reason cancer cells might direct pyruvate to an alterative pathway and what advantage this might provide to cancer cells.
Deanna HettingerLv2
28 Sep 2019
