Question

1/What is the fate of a protein with no N-terminus Signal Sequence?

(a)Transport through the constitutive secretory pathway

(b)Dispersal throughout the cytoplasm

(c)Transport into the nucleus

(d)Transport to the rough endoplasmic reticulum (RER)

2/ In nerve cells, Botulinum toxin-A degrades a subunit of a T-snare localized on the plasma membrane, how would this affect vesicular trafficking?

(a) It blocks the co-translational import of neurotransmitter proteins into the Endoplasmic reticulum via the translocon.

(b) It prevents the addition of carbohydrates to translated proteins

(c)It blocks the fusion of neurotransmitter-containing vesicles with the plasma membrane because theT-snare would not be able tophysically interact with the V-snare.

(d) None of the above

3/

What is the correct order of events of Clathrin-mediated endocytosis?

1. Uncoating of Clathrin- coated vesicle

2. Recruitment of Clathrin and selection of cargo

3. Fusion of vesicle with early endosome

(a) 1, 2, 3

(b) 2, 1, 3

(c) 2, 3, 1

(d) 3, 1, 2

4/ Vesicles traveling anterogradely will eventually fuse with the cell membrane.

Which of the following elements does NOT participate in the fusion event?

(a) v-snare

(b) t-snare

(c) SNARE complex

(d) clathrin coat protein

5/

When a cell releases a hormone into the bloodstream and a number of cells in a

distal location respond, this type of signaling is...

(a) Autocrine signaling

(b) Endocrine signaling

(c) Paracrine signaling

(d) Juxtacrine signaling