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lavendersnail9Lv1

28 Sep 2019

1=Did the suntan lotion(s) appear to have any protective effect on UV-induced mutation? What was the effect of SPF on the results? Is it consistent with the SPF on the container? Explain account the differences observed upon longer exposure

2= What is the relationship between DNA damage, mutation and cell death? Why does exposure to sun damage your skin? Explain.

3= Do you see colonies on the control plate? If so, why? If not, why do you think I asked this question?

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Irving HeathcoteLv2

28 Sep 2019

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The Case of the Aging Surfer

Seth, a thirty-eight year-old white male of Scandinavian descent, has lived his entire life in Southern Florida. He is very concerned with maintaining a "healthy" appearance. Seth is very athletic and especially enjoys surfing. He has been surfing since the age of twelve and he started making surfboards while he was in high school. After obtaining a college degree in marketing Seth decided to start his own business making surfboards and giving surfing lessons for a local resort near his home. During a routine physical examination the physician assistant that Seth sees commented on the presence and appearance of a small growth (approximately 2-cm in diameter) above Seth's right eyebrow. This growth was shiny with a pearly border, a central ulcer and engorged surface blood vessels. The physician assistant was concerned that this might be a tumor and asked Seth a number of questions to aid in the diagnosis. Seth reported that he noticed this growth approximately six months ago but thought nothing about it since he often developed "pimples" when he was working on surfboards because of the heat and dust. Seth noticed that the growth would occasionally bleed, but he thought the bleeding most often occurred when he absently scratched above his eyebrows when he was working. Seth also reported that after bleeding the growth would "crust over" and appear to heal, but not disappear. Seth also thinks the lesion has increased in size, but he can't be certain.

The physician assistant asks Seth to come back in two days to visit with the attending physician and encourages Seth to be sure to use sunscreen whenever possible, especially when he is surfing or teaching surfing classes. Upon returning to see the physician, Seth is told that he probably has a basal cell carcinoma. This, the physician explains, is a cancer that while not benign, rarely metastasizes and grows very slowly. This type of cancer usually occurs in areas that have the greatest exposure to the sun (i.e. the face, head, and neck). While this cancer would probably not metastasize, the physician suggests surgical removal to minimize damage to any underlying tissues and a histological examination of the excised tissue to confirm the diagnosis.

Seth is concerned that if this is indeed cancer he will have to undergo radiation and/or chemotherapy and suffer from both hair loss and nausea like his mother did when she was being treated for breast cancer 10 years ago. The physician assures Seth that these treatments are not required for basal cell carcinoma and explains that this cancer usually remains localized to the specific area of the skin and does not usually spread to other tissues, so radiation and chemotherapy would not be necessary. Seth then asks why it is necessary to remove the tumor if it will not spread and is told that while the tumor does not spread to other body areas it will continue to grow and also invade deeper layers of the skin, such as the dermis, and destroy normal tissues. Seth agrees to the procedure and schedules a follow-up appointment to discuss the results of the biopsy the following week. At the follow-up appointment, Seth is told that the lesion was indeed a basal cell carcinoma. He is told that it will be important for him to try to use both sunscreens, specifically those containing para-aminobenzoic acid or PABA, and protective clothing as much as possible to minimize the effects of the ultraviolet (UV) rays of the sunlight. Seth is also told that while he should not be overly concerned, he should also pay close attention for similar lesions in the future, since a person with a single basal cell carcinoma is likely to develop additional basal cell carcinomas in the future.

http://emedicine.com/derm/topic47.htm

http://www.skincancer.org

The Case of the Aging Surfer:

Define the bold terms in the text.

How are benign and malignant tumors similar and different from each other?

Identify and briefly describe the three most common types of skin cancer and the risk to individuals who have developed each of them.

What are oncogenes and how are they believed to be related to cancer?.

Identify both the primary risk factors that Seth presents with and other risk factors that may or may not relate to Seth's case.

The procedure that Seth experiences is called the Mohs Surgery. What does it involve?

How do chemotherapy and radiation therapy act as treatments for cancer?

8) Explain why tanning booths are actually more dangerous than sunlight exposure in increasing the risk of developing some form of skin cancer.

Review Questions for Chapter 5: Control of Microbial Growth

1. Consider the following statement: âThorough handwashing with soap and water is the most important step in stopping the spread of many infectious diseasesâ.

a. Explain this statement.

b. Following thorough handwashing with soap, are your hands sterile? Why or why not?

2. If pasteurization does not achieve sterilization, why is pasteurization used to treat food? Why not just heat the food instead?

3. Consider the use of salts and sugars to preserve food.

a. How do salts and sugars preserve foods?

b. Why are these considered physical rather than chemical methods of microbial control?

c. Name one food that is preserved with sugar and one preserved with salt.

d. How do you account for the occasional growth of Penicillium mold in jelly, which is 50% sucrose?

4. Consider dried fruit you can buy at the store (e.g., raisins, pineapples, figs, dates, etc.) Dried fruits date back thousands of years B.C.

a. Why is this such an effective method of preserving food? Suggest several possibilities.

b. Fruit is often dried by being placed outside in the open under the sun in conditions that are not exactly sanitized. Why is this practice generally very safe?

5. There is great concern over healthcare-associated infections.

a. Why are healthcare settings such a âgoodâ place to catch infectious diseases? List several reasons.

b. What are several effective approaches that healthcare settings can take to minimize the spread of infectious disease?

6. Flying on an airplane includes lots of individuals in close quarters for potentially long periods of time.

a. What technology do you think airplanes use to reduce the amount of microbes from the air?

b. Despite this control method, there have been a number of documented cases of individuals infected with tuberculosis infecting other passengers during a flight. Explain how you think this happened. Which patients are at highest risk for infection, and what does this tell you about the effectiveness of microbial control on an airplane?

7. The thermal death time for a suspension of Bacillus subtilis endospores is 20 minutes in dry heat and less than 10 minutes in an autoclave. Which type of heat is more effective? Why?

8. A large hospital washes burn patients in a stainless steel tub. After each patient, the tub is cleaned with a quat. It was noticed that 14 of 20 burn patients acquired Pseudomonas infections

after being bathed. Provide an explanation for this high rate of infection.

9. If youâre on a municipal water supply, the water coming out of your faucet is chlorinated at the water treatment plant.

a. Is the water coming out of your faucet sterile?

b. Does the water still contain chlorine?

c. What are advantages and disadvantages of chlorine compared with other approaches (e.g., UV treatment, treatment with ozone).

10. You are a member of Engineers Without Borders, and your local chapter has been asked by a rural village in Thailand to assist them with improving their water supply, which they suspect of making villagers sick. The village has piping infrastructure that delivers water through a series of pipes to each household. Upon your initial site assessment of the village, you and your team determine that the water has high turbidity (particulate material) as well as a high bacterial count.

a. Design a strategy for treating the water to make it safe to drink that still relies upon the distribution system. Note that you may make some reasonable assumptions about conditions in the village (e.g., availability of electricity if you wish).

b. Identify some possible limitations of your approach.

11. A low technology approach to treating water in rural locations is to fill clear plastic soda bottles with water and leave it out all day in the sun (e.g., up on a roof).

a. What two factors are most likely at work in controlling microbes in these conditions?

b. What impact does each factor have on the microbes? Be specific.