1. a. Consider the following sequences, which are pieces of a larger, independently folding polypeptide. Which sequence is more likely to form an alpha helix, and which is more likely to form a beta-hairpinâa two-stranded antiparallel beta-sheet in which the strands are separated by a turn?
Sequence A: I F I C T T G P N A T V I C V F V
Sequence B: M D R L M E A M A K L D H L L A E
b. How do the structures of the residues I, V, and T versus L and M contribute to the conformational preferences of these two sequences?
c. Which residues likely form the turn between the stands in the beta-hairpin? Why are these residues suited for this structure?
1. a. Consider the following sequences, which are pieces of a larger, independently folding polypeptide. Which sequence is more likely to form an alpha helix, and which is more likely to form a beta-hairpinâa two-stranded antiparallel beta-sheet in which the strands are separated by a turn?
Sequence A: I F I C T T G P N A T V I C V F V
Sequence B: M D R L M E A M A K L D H L L A E
b. How do the structures of the residues I, V, and T versus L and M contribute to the conformational preferences of these two sequences?
c. Which residues likely form the turn between the stands in the beta-hairpin? Why are these residues suited for this structure?
Related textbook solutions
Related questions
1. A sequence of amino acids in a certain protein is found to be â Ser â Gly â Pro â Gly â
The sequence is most probably part of a(n):
a. beta turn
b. antiparallel beta sheet
c. alpha-helix
d. parallel beta-sheet
e. alapha-sheet
2. Which statement about peptides bonds is NOT TRUE?
| There is perfectly free rotation about the peptide bond. | |||||||||||
| The peptide bond has partial double-bond character. | |||||||||||
| The peptide bond is shorter than a normal carbon-nitrogen single bond. | |||||||||||
| The peptide bond usually has a trans configuration with respect to the alpha-carbons of the two amino acids involved in the peptide bond. | |||||||||||
| Peptide bonds are made via condensation of an amine and a carboxylic acid with loss of water. 3. Which of the following statements about proteins is FALSE?
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Match each term with its definition. Each term or definition is used only once
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